Activation of cell-survival signal Akt by GDNF in normal rat brain

G. Jin, N. Omori, F. Li, K. Sato, I. Nagano, Y. Manabe, M. Shoji, K. Abe

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Glial cell line-derived neurotrophic factor (GDNF) activates protein kinase Akt/PKB by phosphorylation (p-Akt) which plays key roles in cell survival. In the current study, we investigated a temporal expression of p-Akt by immunohistochemical analysis after a topical application of GDNF to normal cerebral hemisphere of rats. Although p-Akt immunoreactivity was weakly present in the sham control neural cells, GDNF application greatly enhanced it at 3 h, which lasted until 1 day. These results indicate that p-Akt is expressed in neuronal cells under physiological conditions, and that topical application of GDNF greatly enhanced the phosphorylation of Akt in normal rat brain.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalBrain Research
Issue number2
Publication statusPublished - Dec 27 2002


  • Glial cell line-derived neurotrophic factor
  • Phospho-Akt
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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