Abstract
Glial cell line-derived neurotrophic factor (GDNF) activates protein kinase Akt/PKB by phosphorylation (p-Akt) which plays key roles in cell survival. In the current study, we investigated a temporal expression of p-Akt by immunohistochemical analysis after a topical application of GDNF to normal cerebral hemisphere of rats. Although p-Akt immunoreactivity was weakly present in the sham control neural cells, GDNF application greatly enhanced it at 3 h, which lasted until 1 day. These results indicate that p-Akt is expressed in neuronal cells under physiological conditions, and that topical application of GDNF greatly enhanced the phosphorylation of Akt in normal rat brain.
| Original language | English |
|---|---|
| Pages (from-to) | 429-433 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 958 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Dec 27 2002 |
Keywords
- Glial cell line-derived neurotrophic factor
- Phospho-Akt
- Rat
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Jin, G., Omori, N., Li, F., Sato, K., Nagano, I., Manabe, Y., Shoji, M., & Abe, K. (2002). Activation of cell-survival signal Akt by GDNF in normal rat brain. Brain Research, 958(2), 429-433. https://doi.org/10.1016/S0006-8993(02)03521-7