Activation of c-Jun N-terminal kinase during ischemia and reperfusion in mouse liver

Ichiro Onishi, Takashi Tani, Tetsuo Hashimoto, Kouichi Shimizu, Masao Yagi, Ken Ichi Yamamoto, Katsuji Yoshioka

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

We have generated a mouse model for hepatic ischemia in which surgical subcutaneous transposition of the spleen allows hepatic ischemia to be applied without affecting other tissues. Using this mouse model we investigated the relationship between the length of ischemic periods in the liver and subsequent liver function; furthermore, we assayed the activation of c-Jun N-terminal kinase (JNK) during ischemia and reperfusion. Although prior to this study only the activated form of JNK was known to be translocated to the nucleus, we found that JNK translocates to the nucleus during ischemia without activation and is then activated during reperfusion. These results suggest a novel mechanism of JNK activation.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalFEBS Letters
Volume420
Issue number2-3
DOIs
Publication statusPublished - Dec 29 1997
Externally publishedYes

Keywords

  • Ischemia
  • Mitogen-activated protein kinase
  • Signal transduction
  • Stress-activated protein kinase
  • c-Jun N-terminal kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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