Activation of antioxidant system by low dose radiation and its applicable possibility for treatment of reactive oxygen species-related diseases

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We clarified that adequate oxygen stress induced by low dose irradiation activates not only chemical biological protective function, such as induction of the synthesis of superoxide dismutase, glutathione peroxidase, and heat shock protein 70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose irradiation can contribute to suppressing aging and to preventing or reducing reactive oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose irradiation or radon inhalation on the functions of the living body, including adaptive response.

Original languageEnglish
Pages (from-to)114-133
Number of pages20
JournalJournal of Clinical Biochemistry and Nutrition
Volume39
Issue number3
DOIs
Publication statusPublished - 2006

Fingerprint

Radon
Dosimetry
radon
reactive oxygen species
Reactive Oxygen Species
Antioxidants
irradiation
Chemical activation
Radiation
antioxidants
Membrane Fluidity
HSP70 Heat-Shock Proteins
Irradiation
Glutathione Peroxidase
dosage
Inhalation
Superoxide Dismutase
Adenosine Triphosphatases
Diabetes Mellitus
membrane fluidity

Keywords

  • Adaptive response
  • Antioxidant system
  • Low dose irradiation
  • Radon inhalation
  • Reactive oxygen species related diseases

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

@article{492a5566380c4a1b905e1dae5996fd13,
title = "Activation of antioxidant system by low dose radiation and its applicable possibility for treatment of reactive oxygen species-related diseases",
abstract = "We clarified that adequate oxygen stress induced by low dose irradiation activates not only chemical biological protective function, such as induction of the synthesis of superoxide dismutase, glutathione peroxidase, and heat shock protein 70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose irradiation can contribute to suppressing aging and to preventing or reducing reactive oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose irradiation or radon inhalation on the functions of the living body, including adaptive response.",
keywords = "Adaptive response, Antioxidant system, Low dose irradiation, Radon inhalation, Reactive oxygen species related diseases",
author = "Kiyonori Yamaoka",
year = "2006",
doi = "10.3164/jcbn.39.114",
language = "English",
volume = "39",
pages = "114--133",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "3",

}

TY - JOUR

T1 - Activation of antioxidant system by low dose radiation and its applicable possibility for treatment of reactive oxygen species-related diseases

AU - Yamaoka, Kiyonori

PY - 2006

Y1 - 2006

N2 - We clarified that adequate oxygen stress induced by low dose irradiation activates not only chemical biological protective function, such as induction of the synthesis of superoxide dismutase, glutathione peroxidase, and heat shock protein 70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose irradiation can contribute to suppressing aging and to preventing or reducing reactive oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose irradiation or radon inhalation on the functions of the living body, including adaptive response.

AB - We clarified that adequate oxygen stress induced by low dose irradiation activates not only chemical biological protective function, such as induction of the synthesis of superoxide dismutase, glutathione peroxidase, and heat shock protein 70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose irradiation can contribute to suppressing aging and to preventing or reducing reactive oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose irradiation or radon inhalation on the functions of the living body, including adaptive response.

KW - Adaptive response

KW - Antioxidant system

KW - Low dose irradiation

KW - Radon inhalation

KW - Reactive oxygen species related diseases

UR - http://www.scopus.com/inward/record.url?scp=34248643998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248643998&partnerID=8YFLogxK

U2 - 10.3164/jcbn.39.114

DO - 10.3164/jcbn.39.114

M3 - Article

AN - SCOPUS:34248643998

VL - 39

SP - 114

EP - 133

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 3

ER -