Activating stimulatory G protein alpha mutations do not occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw

Eiki Yamachika, Hidetsugu Tsujigiwa, Nobuyoshi Mizukawa, Masakazu Matsubara, Toshio Sugahara

Research output: Contribution to journalArticle

Abstract

Objective: Activating mutations within the stimulatory G protein alpha gene are typically associated with the McCune-Albright syndrome. These mutations have been found in endocrine tumours, intramuscular myxomas, and polyostotic fibrous dysplasias of bone inpatients with McCune-Albright syndrome. We hypothesised that the same mutations might occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. In this study, we aimed to clarify the association between these tumours and mutations in the stimulatory G protein alpha gene. Materials and Methods: Paraffin-embedded specimens of 5 cases each of odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw were examined. Exon 8 and exon 9 of the stimulatory G protein alpha gene were screened by polymerase chain reaction-single-stranded conformation polymorphism analysis, and the polymerase chain reaction products were then sequenced using the dideoxy method. Results: No activating mutations of the stimulatory G protein alpha gene were found in any of the cases of odontogenic myxoma or monostotic fibrous dysplasia of bone in the jaw. Conclusions: Odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw are most likely not associated with activating mutations of the stimulatory G protein alpha gene.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalAsian Journal of Oral and Maxillofacial Surgery
Volume19
Issue number3
Publication statusPublished - 2007

Fingerprint

Monostotic Fibrous Dysplasia
Fibrous Dysplasia of Bone
Myxoma
Jaw
GTP-Binding Proteins
Polyostotic Fibrous Dysplasia
Mutation
Genes
Exons
Polymerase Chain Reaction
Paraffin
Inpatients
Neoplasms

Keywords

  • Fibrous dysplasia
  • GS
  • GTP-binding protein alpha subunits
  • Monostotic
  • Mutation
  • Myxoma
  • Odontogenic tumors

ASJC Scopus subject areas

  • Surgery

Cite this

Activating stimulatory G protein alpha mutations do not occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. / Yamachika, Eiki; Tsujigiwa, Hidetsugu; Mizukawa, Nobuyoshi; Matsubara, Masakazu; Sugahara, Toshio.

In: Asian Journal of Oral and Maxillofacial Surgery, Vol. 19, No. 3, 2007, p. 133-137.

Research output: Contribution to journalArticle

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T1 - Activating stimulatory G protein alpha mutations do not occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw

AU - Yamachika, Eiki

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AU - Matsubara, Masakazu

AU - Sugahara, Toshio

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N2 - Objective: Activating mutations within the stimulatory G protein alpha gene are typically associated with the McCune-Albright syndrome. These mutations have been found in endocrine tumours, intramuscular myxomas, and polyostotic fibrous dysplasias of bone inpatients with McCune-Albright syndrome. We hypothesised that the same mutations might occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. In this study, we aimed to clarify the association between these tumours and mutations in the stimulatory G protein alpha gene. Materials and Methods: Paraffin-embedded specimens of 5 cases each of odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw were examined. Exon 8 and exon 9 of the stimulatory G protein alpha gene were screened by polymerase chain reaction-single-stranded conformation polymorphism analysis, and the polymerase chain reaction products were then sequenced using the dideoxy method. Results: No activating mutations of the stimulatory G protein alpha gene were found in any of the cases of odontogenic myxoma or monostotic fibrous dysplasia of bone in the jaw. Conclusions: Odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw are most likely not associated with activating mutations of the stimulatory G protein alpha gene.

AB - Objective: Activating mutations within the stimulatory G protein alpha gene are typically associated with the McCune-Albright syndrome. These mutations have been found in endocrine tumours, intramuscular myxomas, and polyostotic fibrous dysplasias of bone inpatients with McCune-Albright syndrome. We hypothesised that the same mutations might occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. In this study, we aimed to clarify the association between these tumours and mutations in the stimulatory G protein alpha gene. Materials and Methods: Paraffin-embedded specimens of 5 cases each of odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw were examined. Exon 8 and exon 9 of the stimulatory G protein alpha gene were screened by polymerase chain reaction-single-stranded conformation polymorphism analysis, and the polymerase chain reaction products were then sequenced using the dideoxy method. Results: No activating mutations of the stimulatory G protein alpha gene were found in any of the cases of odontogenic myxoma or monostotic fibrous dysplasia of bone in the jaw. Conclusions: Odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw are most likely not associated with activating mutations of the stimulatory G protein alpha gene.

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