Abstract
Objective: Activating mutations within the stimulatory G protein alpha gene are typically associated with the McCune-Albright syndrome. These mutations have been found in endocrine tumours, intramuscular myxomas, and polyostotic fibrous dysplasias of bone inpatients with McCune-Albright syndrome. We hypothesised that the same mutations might occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. In this study, we aimed to clarify the association between these tumours and mutations in the stimulatory G protein alpha gene. Materials and Methods: Paraffin-embedded specimens of 5 cases each of odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw were examined. Exon 8 and exon 9 of the stimulatory G protein alpha gene were screened by polymerase chain reaction-single-stranded conformation polymorphism analysis, and the polymerase chain reaction products were then sequenced using the dideoxy method. Results: No activating mutations of the stimulatory G protein alpha gene were found in any of the cases of odontogenic myxoma or monostotic fibrous dysplasia of bone in the jaw. Conclusions: Odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw are most likely not associated with activating mutations of the stimulatory G protein alpha gene.
| Original language | English |
|---|---|
| Pages (from-to) | 133-137 |
| Number of pages | 5 |
| Journal | Asian Journal of Oral and Maxillofacial Surgery |
| Volume | 19 |
| Issue number | 3 |
| Publication status | Published - 2007 |
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Keywords
- Fibrous dysplasia
- GS
- GTP-binding protein alpha subunits
- Monostotic
- Mutation
- Myxoma
- Odontogenic tumors
ASJC Scopus subject areas
- Surgery
Cite this
Activating stimulatory G protein alpha mutations do not occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. / Yamachika, Eiki; Tsujigiwa, Hidetsugu; Mizukawa, Nobuyoshi; Matsubara, Masakazu; Sugahara, Toshio.
In: Asian Journal of Oral and Maxillofacial Surgery, Vol. 19, No. 3, 2007, p. 133-137.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activating stimulatory G protein alpha mutations do not occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw
AU - Yamachika, Eiki
AU - Tsujigiwa, Hidetsugu
AU - Mizukawa, Nobuyoshi
AU - Matsubara, Masakazu
AU - Sugahara, Toshio
PY - 2007
Y1 - 2007
N2 - Objective: Activating mutations within the stimulatory G protein alpha gene are typically associated with the McCune-Albright syndrome. These mutations have been found in endocrine tumours, intramuscular myxomas, and polyostotic fibrous dysplasias of bone inpatients with McCune-Albright syndrome. We hypothesised that the same mutations might occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. In this study, we aimed to clarify the association between these tumours and mutations in the stimulatory G protein alpha gene. Materials and Methods: Paraffin-embedded specimens of 5 cases each of odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw were examined. Exon 8 and exon 9 of the stimulatory G protein alpha gene were screened by polymerase chain reaction-single-stranded conformation polymorphism analysis, and the polymerase chain reaction products were then sequenced using the dideoxy method. Results: No activating mutations of the stimulatory G protein alpha gene were found in any of the cases of odontogenic myxoma or monostotic fibrous dysplasia of bone in the jaw. Conclusions: Odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw are most likely not associated with activating mutations of the stimulatory G protein alpha gene.
AB - Objective: Activating mutations within the stimulatory G protein alpha gene are typically associated with the McCune-Albright syndrome. These mutations have been found in endocrine tumours, intramuscular myxomas, and polyostotic fibrous dysplasias of bone inpatients with McCune-Albright syndrome. We hypothesised that the same mutations might occur in odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw. In this study, we aimed to clarify the association between these tumours and mutations in the stimulatory G protein alpha gene. Materials and Methods: Paraffin-embedded specimens of 5 cases each of odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw were examined. Exon 8 and exon 9 of the stimulatory G protein alpha gene were screened by polymerase chain reaction-single-stranded conformation polymorphism analysis, and the polymerase chain reaction products were then sequenced using the dideoxy method. Results: No activating mutations of the stimulatory G protein alpha gene were found in any of the cases of odontogenic myxoma or monostotic fibrous dysplasia of bone in the jaw. Conclusions: Odontogenic myxoma and monostotic fibrous dysplasia of bone in the jaw are most likely not associated with activating mutations of the stimulatory G protein alpha gene.
KW - Fibrous dysplasia
KW - GS
KW - GTP-binding protein alpha subunits
KW - Monostotic
KW - Mutation
KW - Myxoma
KW - Odontogenic tumors
UR - http://www.scopus.com/inward/record.url?scp=41849107565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41849107565&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:41849107565
VL - 19
SP - 133
EP - 137
JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
SN - 2212-5558
IS - 3
ER -