Activated T cells and soluble molecules in the portal venous blood of patients with cholestatic and hepatitis C virus-positive liver cirrhosis. Possible promotion of Fas/FasL-mediated apoptosis in the bile-duct cells and hepatocyte injury

N. Ariki, Y. Morimoto, T. Yagi, T. Oyama, Y. Cyouda, H. Sadamori, M. Inagaki, N. Urushihara, H. Iwagaki, N. Tanaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated the immune responses of patients with cholestatic and hepatitis C virus-positive (HCV-positive) liver cirrhosis by analysing T-cell subsets and cytokine levels in the portal and peripheral veins, using flow cytometry and enzyme-linked immunosorbent assay. In cholestatic liver cirrhosis, the proportion of natural-killer (NK) T cells and interleukin (IL) 6 and IL-18 levels in the portal venous blood were significantly higher than those in the peripheral venous blood. In HCV-positive liver cirrhosis, the proportions of NK T cells and Fas+ T cells and IL-6 and soluble Fas levels in the portal venous blood were significantly higher than those in the peripheral venous blood. These results suggest that in these diseases, activated T cells and soluble molecules in portal venous blood may promote Fas/FasL-mediated apoptosis of the bile-duct cells and hepatocytes, and contribute to the deterioration in liver function as an inevitable result of positive feedback.

Original languageEnglish
Pages (from-to)170-180
Number of pages11
JournalJournal of International Medical Research
Volume31
Issue number3
DOIs
Publication statusPublished - 2003

Keywords

  • Apoptosis
  • Cholestatic liver cirrhosis
  • Fas
  • Fas-ligand
  • HCV-positive liver cirrhosis
  • Interleukin 18
  • Interleukin 6
  • Natural-killer T cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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