Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum

Shunji Hitotsubashi, Masaaki Akagi, Akihiko Saitou, Hiroyasu Yamanaka, Uoshio Fujii, Keinosuke Okamoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 μg/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10-6 M), but was abolished by the addition of papaverine (10-4 M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalFEMS Microbiology Letters
Volume90
Issue number3
DOIs
Publication statusPublished - Jan 15 1992
Externally publishedYes

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Ileum
Escherichia coli
Serous Membrane
Papaverine
Atropine
Muscle Cells
Intestines
Mucous Membrane
heat stable toxin (E coli)

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum. / Hitotsubashi, Shunji; Akagi, Masaaki; Saitou, Akihiko; Yamanaka, Hiroyasu; Fujii, Uoshio; Okamoto, Keinosuke.

In: FEMS Microbiology Letters, Vol. 90, No. 3, 15.01.1992, p. 249-252.

Research output: Contribution to journalArticle

Hitotsubashi, Shunji ; Akagi, Masaaki ; Saitou, Akihiko ; Yamanaka, Hiroyasu ; Fujii, Uoshio ; Okamoto, Keinosuke. / Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum. In: FEMS Microbiology Letters. 1992 ; Vol. 90, No. 3. pp. 249-252.
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