When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 μg/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10-6 M), but was abolished by the addition of papaverine (10-4 M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.
ASJC Scopus subject areas
- Molecular Biology