Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum

Shunji Hitotsubashi, Masaaki Akagi, Akihiko Saitou, Hiroyasu Yamanaka, Uoshio Fujii, Keinosuke Okamoto

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When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 μg/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10-6 M), but was abolished by the addition of papaverine (10-4 M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalFEMS Microbiology Letters
Issue number3
Publication statusPublished - Jan 15 1992
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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