TY - JOUR
T1 - Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum
AU - Hitotsubashi, Shunji
AU - Akagi, Masaaki
AU - Saitou, Akihiko
AU - Yamanaka, Hiroyasu
AU - Fujii, Uoshio
AU - Okamoto, Keinosuke
PY - 1992/1/15
Y1 - 1992/1/15
N2 - When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 μg/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10-6 M), but was abolished by the addition of papaverine (10-4 M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.
AB - When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 μg/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10-6 M), but was abolished by the addition of papaverine (10-4 M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.
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U2 - 10.1016/0378-1097(92)90655-8
DO - 10.1016/0378-1097(92)90655-8
M3 - Article
C2 - 1555760
AN - SCOPUS:0027119497
SN - 0378-1097
VL - 90
SP - 249
EP - 252
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 3
ER -