Abstract

The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

Original languageEnglish
JournalBrain and Development
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Anticonvulsants
Neurons
Synapses
Epilepsy
Membranes
Pharmaceutical Preparations
Therapeutics

Keywords

  • Epilepsy
  • GABA
  • Mechanisms
  • Seizure
  • Sodium channel blocker
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

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title = "Action of antiepileptic drugs on neurons",
abstract = "The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.",
keywords = "Epilepsy, GABA, Mechanisms, Seizure, Sodium channel blocker, Treatment",
author = "Katsuhiro Kobayashi and Fumika Endoh and Iori Ohmori and Tomoyuki Akiyama",
year = "2019",
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journal = "Brain and Development",
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T1 - Action of antiepileptic drugs on neurons

AU - Kobayashi, Katsuhiro

AU - Endoh, Fumika

AU - Ohmori, Iori

AU - Akiyama, Tomoyuki

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Y1 - 2019/1/1

N2 - The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

AB - The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

KW - Epilepsy

KW - GABA

KW - Mechanisms

KW - Seizure

KW - Sodium channel blocker

KW - Treatment

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