TY - JOUR
T1 - Action of antiepileptic drugs on neurons
AU - Kobayashi, Katsuhiro
AU - Endoh, Fumika
AU - Ohmori, Iori
AU - Akiyama, Tomoyuki
N1 - Funding Information:
K. Kobayashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05874 [Non-linear Neuro-oscillology]) and by Health and Labour Research Grants from the Ministry of Health, Labour and Welfare, Japan (H24-nanchitou-ippan-029, H26-nanchitou-ippan-051, and H29-nanchitou-ippan-010). T. Akiyama was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number JP15K09622 ).
Publisher Copyright:
© 2019 The Japanese Society of Child Neurology
PY - 2020/1
Y1 - 2020/1
N2 - The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.
AB - The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.
KW - Epilepsy
KW - GABA
KW - Mechanisms
KW - Seizure
KW - Sodium channel blocker
KW - Treatment
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U2 - 10.1016/j.braindev.2019.07.006
DO - 10.1016/j.braindev.2019.07.006
M3 - Review article
C2 - 31351738
AN - SCOPUS:85069724332
VL - 42
SP - 2
EP - 5
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 1
ER -