Action of antiepileptic drugs on neurons

Katsuhiro Kobayashi; Fumika Endoh; Iori Ohmori; Tomoyuki Akiyama

doi:10.1016/j.braindev.2019.07.006

Action of antiepileptic drugs on neurons

Katsuhiro Kobayashi, Fumika Endoh, Iori Ohmori, Tomoyuki Akiyama

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

Original language	English
Pages (from-to)	2-5
Number of pages	4
Journal	Brain and Development
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.braindev.2019.07.006
Publication status	Published - Jan 2020

Keywords

Epilepsy
GABA
Mechanisms
Seizure
Sodium channel blocker
Treatment

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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title = "Action of antiepileptic drugs on neurons",

abstract = "The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.",

keywords = "Epilepsy, GABA, Mechanisms, Seizure, Sodium channel blocker, Treatment",

author = "Katsuhiro Kobayashi and Fumika Endoh and Iori Ohmori and Tomoyuki Akiyama",

note = "Funding Information: K. Kobayashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05874 [Non-linear Neuro-oscillology]) and by Health and Labour Research Grants from the Ministry of Health, Labour and Welfare, Japan (H24-nanchitou-ippan-029, H26-nanchitou-ippan-051, and H29-nanchitou-ippan-010). T. Akiyama was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number JP15K09622 ).",

year = "2020",

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doi = "10.1016/j.braindev.2019.07.006",

language = "English",

volume = "42",

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T1 - Action of antiepileptic drugs on neurons

AU - Kobayashi, Katsuhiro

AU - Endoh, Fumika

AU - Ohmori, Iori

AU - Akiyama, Tomoyuki

N1 - Funding Information: K. Kobayashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05874 [Non-linear Neuro-oscillology]) and by Health and Labour Research Grants from the Ministry of Health, Labour and Welfare, Japan (H24-nanchitou-ippan-029, H26-nanchitou-ippan-051, and H29-nanchitou-ippan-010). T. Akiyama was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number JP15K09622 ).

PY - 2020/1

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N2 - The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

AB - The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

KW - Epilepsy

KW - GABA

KW - Mechanisms

KW - Seizure

KW - Sodium channel blocker

KW - Treatment

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