Action of antiepileptic drugs on neurons

Katsuhiro Kobayashi, Fumika Endoh, Iori Ohmori, Tomoyuki Akiyama

Research output: Contribution to journal › Review article

Abstract

The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

Original languageEnglish
JournalBrain and Development
DOIs
Publication statusPublished - Jan 1 2019

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Anticonvulsants
Neurons
Synapses
Epilepsy
Membranes
Pharmaceutical Preparations
Therapeutics

Keywords

  • Epilepsy
  • GABA
  • Mechanisms
  • Seizure
  • Sodium channel blocker
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Action of antiepileptic drugs on neurons. / Kobayashi, Katsuhiro; Endoh, Fumika; Ohmori, Iori; Akiyama, Tomoyuki.

In: Brain and Development, 01.01.2019.

Research output: Contribution to journal › Review article

Kobayashi, K, Endoh, F, Ohmori, I & Akiyama, T 2019, 'Action of antiepileptic drugs on neurons', Brain and Development. https://doi.org/10.1016/j.braindev.2019.07.006
Kobayashi K, Endoh F, Ohmori I, Akiyama T. Action of antiepileptic drugs on neurons. Brain and Development. 2019 Jan 1. https://doi.org/10.1016/j.braindev.2019.07.006
Kobayashi, Katsuhiro ; Endoh, Fumika ; Ohmori, Iori ; Akiyama, Tomoyuki. / Action of antiepileptic drugs on neurons. In: Brain and Development. 2019.
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