Action of antiepileptic drugs on neurons

Katsuhiro Kobayashi; Fumika Endoh; Iori Ohmori; Tomoyuki Akiyama

doi:10.1016/j.braindev.2019.07.006

Action of antiepileptic drugs on neurons

Katsuhiro Kobayashi, Fumika Endoh, Iori Ohmori, Tomoyuki Akiyama

Research output: Contribution to journal › Review article

1 Citation (Scopus)

Abstract

The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

Original language	English
Pages (from-to)	2-5
Number of pages	4
Journal	Brain and Development
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.braindev.2019.07.006
Publication status	Published - Jan 2020

Keywords

Epilepsy
GABA
Mechanisms
Seizure
Sodium channel blocker
Treatment

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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Kobayashi, K., Endoh, F., Ohmori, I., & Akiyama, T. (2020). Action of antiepileptic drugs on neurons. Brain and Development, 42(1), 2-5. https://doi.org/10.1016/j.braindev.2019.07.006

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