Action mechanism of human SMUG1 uracil-DNA glycosylase.

Mayumi Matsubara, Tamon Tanaka, Hiroaki Terato, Hiroshi Ide

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The DNA lesions resulting from deamination or oxidation of bases are generally repaired by the base excision repair pathway initiated by damage-specific DNA glycosylases. Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) present in vertebrates and insects excises not only uracil but also uracil derivatives bearing an oxidized group at ring-C5 from DNA, indicating roles in the repair of both deamination and oxidation damage to DNA. In the present study, we have constructed a series of active site mutants of human SMUG1 and analyzed the catalytic and precision damage recognition mechanisms.

Original languageEnglish
Pages (from-to)295-296
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
Publication statusPublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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