Acoustic radiation force impulse elastography of the kidneys: Is shear wave velocity affected by tissue fibrosis or renal blood flow?

Kenichiro Asano, Ai Ogata, Keiko Tanaka, Yoko Ide, Akiko Sankoda, Chieko Kawakita, Mana Nishikawa, Kazuyoshi Ohmori, Masaru Kinomura, Noriaki Shimada, Masaki Fukushima

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Abstract

Objectives: The aim of this study was to identify the main influencing factor of the shear wave velocity (SWV) of the kidneys measured by acoustic radiation force impulse elastography. Methods-The SWV was measured in the kidneys of 14 healthy volunteers and 319 patients with chronic kidney disease. The estimated glomerular filtration rate was calculated by the serum creatinine concentration and age. As an indicator of arteriosclerosis of large vessels, the brachial-ankle pulse wave velocity was measured in 183 patients. Results: Compared to the degree of interobserver and intraobserver deviation, a large variance of SWV values was observed in the kidneys of the patients with chronic kidney disease. Shear wave velocity values in the right and left kidneys of each patient correlated well, with high correlation coefficients (r = 0.580-0.732). The SWV decreased concurrently with a decline in the estimated glomerular filtration rate. A low SWV was obtained in patients with a high brachial-ankle pulse wave velocity. Despite progression of renal fibrosis in the advanced stages of chronic kidney disease, these results were in contrast to findings for chronic liver disease, in which progression of hepatic fibrosis results in an increase in the SWV. Considering that a high brachial-ankle pulse wave velocity represents the progression of arteriosclerosis in the large vessels, the reduction of elasticity succeeding diminution of blood flow was suspected to be the main influencing factor of the SWV in the kidneys. Conclusions: This study indicates that diminution of blood flow may affect SWV values in the kidneys more than the progression of tissue fibrosis. Future studies for reducing data variance are needed for effective use of acoustic radiation force impulse elastography in patients with chronic kidney disease.

Original languageEnglish
Pages (from-to)793-801
Number of pages9
JournalJournal of Ultrasound in Medicine
Volume33
Issue number5
DOIs
Publication statusPublished - May 1 2014

Keywords

  • Acoustic radiation force impulse
  • Brachial-ankle pulse wave velocity
  • Chronic kidney disease
  • Genitourinary ultrasound
  • Renal blood flow
  • Shear wave velocity

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Asano, K., Ogata, A., Tanaka, K., Ide, Y., Sankoda, A., Kawakita, C., Nishikawa, M., Ohmori, K., Kinomura, M., Shimada, N., & Fukushima, M. (2014). Acoustic radiation force impulse elastography of the kidneys: Is shear wave velocity affected by tissue fibrosis or renal blood flow? Journal of Ultrasound in Medicine, 33(5), 793-801. https://doi.org/10.7863/ultra.33.5.793