Acne-associated syndromes: Models for better understanding of acne pathogenesis

W. Chen, B. Obermayer-Pietsch, J. B. Hong, B. C. Melnik, O. Yamasaki, C. Dessinioti, Q. Ju, A. I. Liakou, S. Al-Khuzaei, A. Katsambas, J. Ring, C. C. Zouboulis

Research output: Contribution to journalReview articlepeer-review

74 Citations (Scopus)


Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.

Original languageEnglish
Pages (from-to)637-646
Number of pages10
JournalJournal of the European Academy of Dermatology and Venereology
Issue number6
Publication statusPublished - Jun 2011


  • Apert syndrome
  • PAPA syndrome
  • PCO syndrome
  • SAPHO syndrome
  • acne
  • insulin resistance

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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