Acid-based balance in combined severe hepatic and renal failure: A quantitative analysis

T. Naka, Rinaldo Bellomo, Hiroshi Morimatsu, J. Rocktaschel, L. Wan, P. Gow, P. Angus

Research output: Contribution to journalArticle

9 Citations (Scopus)


Background: Severe hepatic failure (SHF) commonly leads to major changes in acid-base balance status. However, the direct effects of liver failure per se on acid base balance are poorly understood because this condition is usually associated with acute renal failure (ARF). Aim: To assess the effect of SHF on acid-base balance. Design: Retrospective laboratory investigation. Subjects: Thirty-seven critically ill patients with SHF complicated by ARF, and 42 patients with severe ARF without liver failure prior to renal replacement therapy. Intervention: Retrieval of clinical and laboratory data from prospective unit and laboratory databases. Methods: Quantitative acid-base assessment using Stewart-Figge methodology. Comparison of findings between the two groups. Comparison of demographic and clinical features. Results: Patients with combined SHF and ARF were younger and had significantly higher mean bilirubin, ALT and INR levels (p

Original languageEnglish
Pages (from-to)288-294
Number of pages7
JournalInternational Journal of Artificial Organs
Issue number4
Publication statusPublished - Apr 2008
Externally publishedYes



  • Acid-base
  • Acidemia
  • Acidosis
  • Chloride
  • Kidney
  • Lactate
  • Liver

ASJC Scopus subject areas

  • Biophysics

Cite this

Naka, T., Bellomo, R., Morimatsu, H., Rocktaschel, J., Wan, L., Gow, P., & Angus, P. (2008). Acid-based balance in combined severe hepatic and renal failure: A quantitative analysis. International Journal of Artificial Organs, 31(4), 288-294.