Acid-base balance during continuous veno-venous hemofiltration: The impact of severe hepatic failure

T. Naka, Rinaldo Bellomo, Hiroshi Morimatsu, J. Rocktaschel, L. Wan, P. Gow, P. Angus

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Continuous renal replacement therapy (CRRT) affects acid-base balance but the influence of severe hepatic failure (SHF) on this effect is unknown. Aim: To assess the effect of SHF on acid-base balance in patients receiving CVVH. Design: Retrospective laboratory investigation. Subjects: Forty patients with SHF and acute renal failure (ARF) treated with CVVH and 42 critically ill patients with severe ARF but no liver disease also treated with CVVH (controls). Intervention: Retrieval of clinical and laboratory data from prospective unit and laboratory databases. Methods: Quantitative acid-base status assessment using the Stewart-Figge methodology. Comparison of findings between the two groups. Results: Although CVVH had a major effect on acid base balance in both groups, patients with SHF had a higher mean lactate concentrations (4.8 vs. 3.1 mmol/L; p2 tension (36.8 vs. 42.5 mmHg; p

Original languageEnglish
Pages (from-to)668-674
Number of pages7
JournalInternational Journal of Artificial Organs
Volume29
Issue number7
Publication statusPublished - Jul 2006
Externally publishedYes

Fingerprint

Hemofiltration
Acid-Base Equilibrium
Liver Failure
Acute Kidney Injury
Liver
Renal Replacement Therapy
Lactic Acid
Critical Illness
Liver Diseases
Acids
Databases

Keywords

  • Acidemia
  • Acidosis
  • Acute liver failure
  • Acute renal failure
  • Base deficit
  • Hemofiltration
  • Hypoalbumemia
  • Lactate
  • Strong ion gap

ASJC Scopus subject areas

  • Biophysics

Cite this

Acid-base balance during continuous veno-venous hemofiltration : The impact of severe hepatic failure. / Naka, T.; Bellomo, Rinaldo; Morimatsu, Hiroshi; Rocktaschel, J.; Wan, L.; Gow, P.; Angus, P.

In: International Journal of Artificial Organs, Vol. 29, No. 7, 07.2006, p. 668-674.

Research output: Contribution to journalArticle

Naka, T. ; Bellomo, Rinaldo ; Morimatsu, Hiroshi ; Rocktaschel, J. ; Wan, L. ; Gow, P. ; Angus, P. / Acid-base balance during continuous veno-venous hemofiltration : The impact of severe hepatic failure. In: International Journal of Artificial Organs. 2006 ; Vol. 29, No. 7. pp. 668-674.
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AU - Wan, L.

AU - Gow, P.

AU - Angus, P.

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