Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

Eiji Tamai, Tetsuya Ishida, Shigeru Miyata, Osamu Matsushita, Hirofumi Suda, Shoji Kobayashi, Hiroshi Sonobe, Akinobu Okabe

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.

Original languageEnglish
Pages (from-to)5371-5375
Number of pages5
JournalInfection and Immunity
Volume71
Issue number9
DOIs
Publication statusPublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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