Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

Satoshi Kubota; Kazumi Kawata; Takeshi Yanagita; Hideyuki Doi; Takashi Kitoh; Masaharu Takigawa

doi:10.1093/jb/mvh126

Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

Satoshi Kubota, Kazumi Kawata, Takeshi Yanagita, Hideyuki Doi, Takashi Kitoh, Masaharu Takigawa

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

Original language	English
Pages (from-to)	279-282
Number of pages	4
Journal	Journal of biochemistry
Volume	136
Issue number	3
DOIs	https://doi.org/10.1093/jb/mvh126
Publication status	Published - Sep 2004

Keywords

CCN2
CTGF
Platelet
Tissue regeneration
Wound healing

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1093/jb/mvh126

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title = "Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets",

abstract = "Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.",

keywords = "CCN2, CTGF, Platelet, Tissue regeneration, Wound healing",

author = "Satoshi Kubota and Kazumi Kawata and Takeshi Yanagita and Hideyuki Doi and Takashi Kitoh and Masaharu Takigawa",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (S.K., M.T.), and by grants from the Nakatomi Health Science Foundation (S.K.), the Foundation for Growth Science in Japan (M.T.), the Sumitomo Foundation (M.T.), and the Ryobi-teien Memorial Foundation (S.K.). The authors wish to thank Drs. Kyouji Nakao, Nagato Tamamura, and Morihiko Oka for their helpful sug- gestions; Ms. Kazumi Oyama for the technical assistance; and Ms. Yuki Nonami for the secretarial assistance.",

year = "2004",

month = sep,

doi = "10.1093/jb/mvh126",

language = "English",

volume = "136",

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AU - Kubota, Satoshi

AU - Kawata, Kazumi

AU - Yanagita, Takeshi

AU - Doi, Hideyuki

AU - Kitoh, Takashi

AU - Takigawa, Masaharu

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (S.K., M.T.), and by grants from the Nakatomi Health Science Foundation (S.K.), the Foundation for Growth Science in Japan (M.T.), the Sumitomo Foundation (M.T.), and the Ryobi-teien Memorial Foundation (S.K.). The authors wish to thank Drs. Kyouji Nakao, Nagato Tamamura, and Morihiko Oka for their helpful sug- gestions; Ms. Kazumi Oyama for the technical assistance; and Ms. Yuki Nonami for the secretarial assistance.

PY - 2004/9

Y1 - 2004/9

N2 - Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

AB - Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

KW - CCN2

KW - CTGF

KW - Platelet

KW - Tissue regeneration

KW - Wound healing

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Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

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