Abstract
Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.
| Original language | English |
|---|---|
| Pages (from-to) | 279-282 |
| Number of pages | 4 |
| Journal | Journal of biochemistry |
| Volume | 136 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2004 |
Keywords
- CCN2
- CTGF
- Platelet
- Tissue regeneration
- Wound healing
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
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Cite this
Kubota, S., Kawata, K., Yanagita, T., Doi, H., Kitoh, T., & Takigawa, M. (2004). Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. Journal of biochemistry, 136(3), 279-282. https://doi.org/10.1093/jb/mvh126