Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

Satoshi Kubota, Kazumi Kawata, Takeshi Yanagita, Hideyuki Doi, Takashi Kitoh, Masaharu Takigawa

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of Biochemistry
Volume136
Issue number3
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Connective Tissue Growth Factor
Platelets
Blood Platelets
Coagulation
Regeneration
Tissue
Tissue regeneration
Cartilage
Wound Healing
Intercellular Signaling Peptides and Proteins
Fibrosis
Adhesion

Keywords

  • CCN2
  • CTGF
  • Platelet
  • Tissue regeneration
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry

Cite this

Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. / Kubota, Satoshi; Kawata, Kazumi; Yanagita, Takeshi; Doi, Hideyuki; Kitoh, Takashi; Takigawa, Masaharu.

In: Journal of Biochemistry, Vol. 136, No. 3, 09.2004, p. 279-282.

Research output: Contribution to journalArticle

@article{70cf2206e0814fdca44e332763df3f98,
title = "Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets",
abstract = "Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.",
keywords = "CCN2, CTGF, Platelet, Tissue regeneration, Wound healing",
author = "Satoshi Kubota and Kazumi Kawata and Takeshi Yanagita and Hideyuki Doi and Takashi Kitoh and Masaharu Takigawa",
year = "2004",
month = "9",
doi = "10.1093/jb/mvh126",
language = "English",
volume = "136",
pages = "279--282",
journal = "Journal of Biochemistry",
issn = "0021-924X",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

AU - Kubota, Satoshi

AU - Kawata, Kazumi

AU - Yanagita, Takeshi

AU - Doi, Hideyuki

AU - Kitoh, Takashi

AU - Takigawa, Masaharu

PY - 2004/9

Y1 - 2004/9

N2 - Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

AB - Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

KW - CCN2

KW - CTGF

KW - Platelet

KW - Tissue regeneration

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=9144224829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9144224829&partnerID=8YFLogxK

U2 - 10.1093/jb/mvh126

DO - 10.1093/jb/mvh126

M3 - Article

C2 - 15598883

AN - SCOPUS:9144224829

VL - 136

SP - 279

EP - 282

JO - Journal of Biochemistry

JF - Journal of Biochemistry

SN - 0021-924X

IS - 3

ER -