Abstract
Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.
| Original language | English |
|---|---|
| Pages (from-to) | 279-282 |
| Number of pages | 4 |
| Journal | Journal of Biochemistry |
| Volume | 136 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2004 |
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Keywords
- CCN2
- CTGF
- Platelet
- Tissue regeneration
- Wound healing
ASJC Scopus subject areas
- Biochemistry
Cite this
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. / Kubota, Satoshi; Kawata, Kazumi; Yanagita, Takeshi; Doi, Hideyuki; Kitoh, Takashi; Takigawa, Masaharu.
In: Journal of Biochemistry, Vol. 136, No. 3, 09.2004, p. 279-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets
AU - Kubota, Satoshi
AU - Kawata, Kazumi
AU - Yanagita, Takeshi
AU - Doi, Hideyuki
AU - Kitoh, Takashi
AU - Takigawa, Masaharu
PY - 2004/9
Y1 - 2004/9
N2 - Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.
AB - Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.
KW - CCN2
KW - CTGF
KW - Platelet
KW - Tissue regeneration
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=9144224829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9144224829&partnerID=8YFLogxK
U2 - 10.1093/jb/mvh126
DO - 10.1093/jb/mvh126
M3 - Article
C2 - 15598883
AN - SCOPUS:9144224829
VL - 136
SP - 279
EP - 282
JO - Journal of Biochemistry
JF - Journal of Biochemistry
SN - 0021-924X
IS - 3
ER -