Absorption of 3-Amino-1-Methyl-5H-Pyrido[4,3-b]Indole, A Mutagencarcinogen Present in Tryptoph

Toshikiro Kimura, Taiji Nakayama, Yuji Kurosaki, Yasuko Suzuki, Yakae Arimoto, Hikoya Hayatsu

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10 Citations (Scopus)

Abstract

The absorption characteristics of 3-amino-l-methyl-5H-pyrido[4,3-b]indole (Trp- P-2), a mutagen-carcinogen present in tryptophan pyrolysate, in the gastrointestinal tract was investigated in Wistar male rats by an in situ loop technique. Trp-P-2, a weak base with a p orly lipophilic below pH 5 and therefore the gastric absorption was negligible at pH 1.1 and 3.0. On the other hand, this compound was rapidly absorbed from the small intestine even at pH 4.0 and the absorption was even faster at higher pH where the unionized fraction increases. The absorption from the large intestine was also rapid. Although the intestine is one of the major metabolic organs for ingested materials, metabolism of Trp-P-2 by the scraped mucosa of the small intestine was slow in comparison with that in the liver. Formation of direct actingmutagens (towards S. typhimurium TA98) associated with the metabolism was also much slower in the small-intestinal mucosa than in the liver. These results sug gestthat this mutagen is activated mainly after being incorporated into the liver, and are consistent with the liver-specific carcinogenicity of Trp-P-2 in rats.

Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalJapanese Journal of Cancer Research GANN
Volume76
Issue number4
Publication statusPublished - 1985

Keywords

  • Biliary excretion
  • Gastrointestinal absorption
  • Mutagenic activation
  • Portal path way
  • Trp-P-2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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