Absolute stereocmemistry of halichlorine; a potent inhibitor of VCAM-1 induction

Hirokazu Arimoto, Ichiro Hayakawa, Makoto Kuramoto, Daisuke Uemura

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The absolute stereochemistry of a marine alkaloid halichlorine, which significantly inhibits VCAM-1 induction in HUVE cells, was established by synthesis of a degradation product of natural product.

Original languageEnglish
Pages (from-to)861-862
Number of pages2
JournalTetrahedron Letters
Volume39
Issue number8
DOIs
Publication statusPublished - Feb 19 1998
Externally publishedYes

Fingerprint

Stereochemistry
Vascular Cell Adhesion Molecule-1
Biological Products
Alkaloids
Degradation
halichlorine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Absolute stereocmemistry of halichlorine; a potent inhibitor of VCAM-1 induction. / Arimoto, Hirokazu; Hayakawa, Ichiro; Kuramoto, Makoto; Uemura, Daisuke.

In: Tetrahedron Letters, Vol. 39, No. 8, 19.02.1998, p. 861-862.

Research output: Contribution to journalArticle

Arimoto, Hirokazu ; Hayakawa, Ichiro ; Kuramoto, Makoto ; Uemura, Daisuke. / Absolute stereocmemistry of halichlorine; a potent inhibitor of VCAM-1 induction. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 8. pp. 861-862.
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