Absolute stereochemistry of amphidinolide C

Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

(equation presented) The absolute configurations at 12 chiral centers in amphidinolide C (1), a potent cytotoxic 25-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 3S, 4R, 6R, 7R, BR, 12R, 13S, 16S, 20R, 23R, 24R, and 29S by combination of NMR analyses, degradation experiments, and synthesis of the C-1-C-7 segment.

Original languageEnglish
Pages (from-to)1363-1366
Number of pages4
JournalOrganic Letters
Volume3
Issue number9
DOIs
Publication statusPublished - May 3 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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