Absolute configuration of amphidinin A

Takahiro Iwai, Takaaki Kubota, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The absolute configurations at six stereogenic centers in amphidinin A (1), a cytotoxic linear polyketide isolated from a symbiotic marine dinoflagellate, Amphidinium sp., were elucidated to be 2R, 4R, 6S, 9R 11R, and 12S by the combination of J-based configuration analysis, modified Mosher's method, and density-functional theory calculations.

Original languageEnglish
Pages (from-to)1541-1544
Number of pages4
JournalJournal of Natural Products
Volume77
Issue number6
DOIs
Publication statusPublished - Jun 27 2014
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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