Absent skeletal uptake of 99mTc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma

Tomoaki Sasaki, Atsutaka Okizaki, Koji Takahashi, Masayuki Mineta, Kenichi Nagasawa, Yasuomi Fujimoto, Kyuhei Kohda, Tamio Aburano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium- 99m hydroxymethylene-diphosphonate showed the following interesting fi ndings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these fi ndings is rare.

Original languageEnglish
Pages (from-to)595-597
Number of pages3
JournalJapanese Journal of Radiology
Volume29
Issue number8
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Keywords

  • AL-type amyloidosis
  • Multiple myeloma
  • Tc-99m HMDP

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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