Absent audiovisual integration elicited by peripheral stimuli in Parkinson's disease

Yanna Ren, Keisuke Suzuki, Weiping Yang, Yanling Ren, Fengxia Wu, Jiajia Yang, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu, Koichi Hirata

Research output: Contribution to journalArticle

Abstract

The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson's disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p<0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p<0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p>0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD.

LanguageEnglish
Article number1648017
JournalParkinson's Disease
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Parkinson Disease
Sleep
Basal Ganglia
Reaction Time
Analysis of Variance

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Absent audiovisual integration elicited by peripheral stimuli in Parkinson's disease. / Ren, Yanna; Suzuki, Keisuke; Yang, Weiping; Ren, Yanling; Wu, Fengxia; Yang, Jiajia; Takahashi, Satoshi; Ejima, Yoshimichi; Wu, Jinglong; Hirata, Koichi.

In: Parkinson's Disease, Vol. 2018, 1648017, 01.01.2018.

Research output: Contribution to journalArticle

Ren, Yanna ; Suzuki, Keisuke ; Yang, Weiping ; Ren, Yanling ; Wu, Fengxia ; Yang, Jiajia ; Takahashi, Satoshi ; Ejima, Yoshimichi ; Wu, Jinglong ; Hirata, Koichi. / Absent audiovisual integration elicited by peripheral stimuli in Parkinson's disease. In: Parkinson's Disease. 2018 ; Vol. 2018.
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