Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Y. Oji; S. Miyoshi; E. Takahashi; S. Koga; Y. Nakano; Y. Shintani; H. Hirabayashi; A. Matsumura; K. Iuchi; K. Ito; Y. Kishimoto; A. Tsuboi; K. Ikegame; N. Hosen; Y. Oka; H. Ogawa; H. Maeda; S. Hayashi; I. Kawase; H. Sugiyama

Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Y. Oji, S. Miyoshi, E. Takahashi, S. Koga, Y. Nakano, Y. Shintani, H. Hirabayashi, A. Matsumura, K. Iuchi, K. Ito, Y. Kishimoto, A. Tsuboi, K. Ikegame, N. Hosen, Y. Oka, H. Ogawa, H. Maeda, S. Hayashi, I. Kawase, H. Sugiyama

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Neoplasma
Volume	51
Issue number	1
Publication status	Published - Jan 1 2004

Keywords

Mutation
Non-small cell lung cancer
The Wilms' tumor gene
WT1

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{66d7f60ac6df464cb491c0b57d47f47e,

title = "Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers",

abstract = "We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.",

keywords = "Mutation, Non-small cell lung cancer, The Wilms' tumor gene, WT1",

author = "Y. Oji and S. Miyoshi and E. Takahashi and S. Koga and Y. Nakano and Y. Shintani and H. Hirabayashi and A. Matsumura and K. Iuchi and K. Ito and Y. Kishimoto and A. Tsuboi and K. Ikegame and N. Hosen and Y. Oka and H. Ogawa and H. Maeda and S. Hayashi and I. Kawase and H. Sugiyama",

year = "2004",

month = jan,

day = "1",

language = "English",

volume = "51",

pages = "17--20",

journal = "Neoplasma",

issn = "0028-2685",

publisher = "Vydavatel'stvo Slovenkej Akademie Vied/Veda Publishing House of the Slovak Academy of Sciences",

number = "1",

}

TY - JOUR

T1 - Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

AU - Oji, Y.

AU - Miyoshi, S.

AU - Takahashi, E.

AU - Koga, S.

AU - Nakano, Y.

AU - Shintani, Y.

AU - Hirabayashi, H.

AU - Matsumura, A.

AU - Iuchi, K.

AU - Ito, K.

AU - Kishimoto, Y.

AU - Tsuboi, A.

AU - Ikegame, K.

AU - Hosen, N.

AU - Oka, Y.

AU - Ogawa, H.

AU - Maeda, H.

AU - Hayashi, S.

AU - Kawase, I.

AU - Sugiyama, H.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

AB - We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

KW - Mutation

KW - Non-small cell lung cancer

KW - The Wilms' tumor gene

KW - WT1

UR - http://www.scopus.com/inward/record.url?scp=10744221256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744221256&partnerID=8YFLogxK

M3 - Article

C2 - 15004653

AN - SCOPUS:10744221256

SN - 0028-2685

VL - 51

SP - 17

EP - 20

JO - Neoplasma

JF - Neoplasma

IS - 1

ER -

Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this