Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Y. Oji, S. Miyoshi, E. Takahashi, S. Koga, Y. Nakano, Y. Shintani, H. Hirabayashi, A. Matsumura, K. Iuchi, K. Ito, Y. Kishimoto, A. Tsuboi, K. Ikegame, N. Hosen, Y. Oka, H. Ogawa, H. Maeda, S. Hayashi, I. Kawase, H. Sugiyama

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Abstract

We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeoplasma
Volume51
Issue number1
Publication statusPublished - 2004
Externally publishedYes

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Keywords

  • Mutation
  • Non-small cell lung cancer
  • The Wilms' tumor gene
  • WT1

ASJC Scopus subject areas

  • Cancer Research

Cite this

Oji, Y., Miyoshi, S., Takahashi, E., Koga, S., Nakano, Y., Shintani, Y., Hirabayashi, H., Matsumura, A., Iuchi, K., Ito, K., Kishimoto, Y., Tsuboi, A., Ikegame, K., Hosen, N., Oka, Y., Ogawa, H., Maeda, H., Hayashi, S., Kawase, I., & Sugiyama, H. (2004). Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers. Neoplasma, 51(1), 17-20.