Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma

Nobuyuki Kato, Erik Larsson, Maurice Cohen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We examined the RNA expression of a human endogenous provirus, termed ERV3, in 170 human tissue and cell specimens. The highest expression was found in normal placental chorionic villi as mRNAs of 9, 7.3, and 3.5 kb. The 7.3‐kb RNA species was found only in the placenta. ERV3 mRNA was expressed in most other normal and malignant tissues at a level which was 2‐10% of that seen in placenta. However, several tissues and tumor cell lines had higher transcnptional levels, equal to 10–60% of the placental level. In contrast, an almost complete abrogation of ERV3 mRNA expression was noted in choriocarcinoma cell lines and in an invasive hydatidiform mole tissue biopsy. This abrogation was not linked to deletions or rearrangements of the ERV3 genome. It appeared to be unassociated with methylation because the ERV3 provirus was similarly methylated in the DNA of placental chorionic villi and choriocarcinoma cells, and ERV3 transcription in choriocarcinoma cells was not induced by 5‐azacytidine. These results suggest that the loss of ERV3 mRNA expression is associated with susceptibility to choriocarcinoma.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalInternational Journal of Cancer
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 15 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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