Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome: Both repolarization and depolarization abnormalities

Nobuhiro Nishii, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tsunetoyo Namba, Daiji Miura, Kohei Miyaji, Shigeki Hiramatsu, Takeshi Tada, Masato Murakami, Atsuyuki Watanabe, Kimikazu Banba, Yoshiaki Sakai, Kazufumi Nakamura, Takefumi Oka, Tohru Ohe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aims This study sought to examine the action potential duration restitution (APDR) property and conduction delay in Brugada syndrome (BrS) patients. A steeply sloped APDR curve and conduction delay are known to be important determinants for the occurrence of ventricular fibrillation (VF).Methods and resultsEndocardial monophasic action potential was obtained from 39 BrS patients and 9 control subjects using the contact electrode method. Maximum slopes of the APDR curve were obtained at both the right ventricular outflow tract (RVOT) and the right ventricular apex (RVA). The onset of activation delay (OAD) after premature stimulation was examined as a marker of conduction delay. Maximum slope of the APDR curve in BrS patients was significantly steeper than that in control subjects at both the RVOT and the RVA (0.77 ± 0.21 vs. 058 ± 0.14 at RVOT, P = 0.009; 0.98 ± 0.23 vs. 0.62 ± 0.16 at RVA, P = 0.001). The dispersion of maximum slope of the APDR curve between the RVOT and the RVA was also larger in BrS patients than in control subjects. The OAD was significantly longer in BrS patients than in control subjects from the RVOT to RVA and from the RVA to RVOT (from RVOT to RVA: 256 ± 12 vs. 243 ± 7 ms, P = 0.003; from RVA to RVOT: 252 ± 11 vs. 241 ± 9 ms, P = 0.01).ConclusionsAbnormal APDR properties and conduction delay were observed in BrS patients. Both repolarization and depolarization abnormalities are thought to be related to the development of VF in BrS patients.

Original languageEnglish
Pages (from-to)544-552
Number of pages9
JournalEuropace
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Brugada Syndrome
Action Potentials
Ventricular Fibrillation
Electrodes

Keywords

  • Brugada syndrome
  • Conduction delay
  • Monophasic action potential duration
  • Restitution curve
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome : Both repolarization and depolarization abnormalities. / Nishii, Nobuhiro; Nagase, Satoshi; Morita, Hiroshi; Kusano, Kengo Fukushima; Namba, Tsunetoyo; Miura, Daiji; Miyaji, Kohei; Hiramatsu, Shigeki; Tada, Takeshi; Murakami, Masato; Watanabe, Atsuyuki; Banba, Kimikazu; Sakai, Yoshiaki; Nakamura, Kazufumi; Oka, Takefumi; Ohe, Tohru.

In: Europace, Vol. 12, No. 4, 04.2010, p. 544-552.

Research output: Contribution to journalArticle

Nishii, N, Nagase, S, Morita, H, Kusano, KF, Namba, T, Miura, D, Miyaji, K, Hiramatsu, S, Tada, T, Murakami, M, Watanabe, A, Banba, K, Sakai, Y, Nakamura, K, Oka, T & Ohe, T 2010, 'Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome: Both repolarization and depolarization abnormalities', Europace, vol. 12, no. 4, pp. 544-552. https://doi.org/10.1093/europace/eup432
Nishii, Nobuhiro ; Nagase, Satoshi ; Morita, Hiroshi ; Kusano, Kengo Fukushima ; Namba, Tsunetoyo ; Miura, Daiji ; Miyaji, Kohei ; Hiramatsu, Shigeki ; Tada, Takeshi ; Murakami, Masato ; Watanabe, Atsuyuki ; Banba, Kimikazu ; Sakai, Yoshiaki ; Nakamura, Kazufumi ; Oka, Takefumi ; Ohe, Tohru. / Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome : Both repolarization and depolarization abnormalities. In: Europace. 2010 ; Vol. 12, No. 4. pp. 544-552.
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abstract = "Aims This study sought to examine the action potential duration restitution (APDR) property and conduction delay in Brugada syndrome (BrS) patients. A steeply sloped APDR curve and conduction delay are known to be important determinants for the occurrence of ventricular fibrillation (VF).Methods and resultsEndocardial monophasic action potential was obtained from 39 BrS patients and 9 control subjects using the contact electrode method. Maximum slopes of the APDR curve were obtained at both the right ventricular outflow tract (RVOT) and the right ventricular apex (RVA). The onset of activation delay (OAD) after premature stimulation was examined as a marker of conduction delay. Maximum slope of the APDR curve in BrS patients was significantly steeper than that in control subjects at both the RVOT and the RVA (0.77 ± 0.21 vs. 058 ± 0.14 at RVOT, P = 0.009; 0.98 ± 0.23 vs. 0.62 ± 0.16 at RVA, P = 0.001). The dispersion of maximum slope of the APDR curve between the RVOT and the RVA was also larger in BrS patients than in control subjects. The OAD was significantly longer in BrS patients than in control subjects from the RVOT to RVA and from the RVA to RVOT (from RVOT to RVA: 256 ± 12 vs. 243 ± 7 ms, P = 0.003; from RVA to RVOT: 252 ± 11 vs. 241 ± 9 ms, P = 0.01).ConclusionsAbnormal APDR properties and conduction delay were observed in BrS patients. Both repolarization and depolarization abnormalities are thought to be related to the development of VF in BrS patients.",
keywords = "Brugada syndrome, Conduction delay, Monophasic action potential duration, Restitution curve, Ventricular fibrillation",
author = "Nobuhiro Nishii and Satoshi Nagase and Hiroshi Morita and Kusano, {Kengo Fukushima} and Tsunetoyo Namba and Daiji Miura and Kohei Miyaji and Shigeki Hiramatsu and Takeshi Tada and Masato Murakami and Atsuyuki Watanabe and Kimikazu Banba and Yoshiaki Sakai and Kazufumi Nakamura and Takefumi Oka and Tohru Ohe",
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T1 - Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome

T2 - Both repolarization and depolarization abnormalities

AU - Nishii, Nobuhiro

AU - Nagase, Satoshi

AU - Morita, Hiroshi

AU - Kusano, Kengo Fukushima

AU - Namba, Tsunetoyo

AU - Miura, Daiji

AU - Miyaji, Kohei

AU - Hiramatsu, Shigeki

AU - Tada, Takeshi

AU - Murakami, Masato

AU - Watanabe, Atsuyuki

AU - Banba, Kimikazu

AU - Sakai, Yoshiaki

AU - Nakamura, Kazufumi

AU - Oka, Takefumi

AU - Ohe, Tohru

PY - 2010/4

Y1 - 2010/4

N2 - Aims This study sought to examine the action potential duration restitution (APDR) property and conduction delay in Brugada syndrome (BrS) patients. A steeply sloped APDR curve and conduction delay are known to be important determinants for the occurrence of ventricular fibrillation (VF).Methods and resultsEndocardial monophasic action potential was obtained from 39 BrS patients and 9 control subjects using the contact electrode method. Maximum slopes of the APDR curve were obtained at both the right ventricular outflow tract (RVOT) and the right ventricular apex (RVA). The onset of activation delay (OAD) after premature stimulation was examined as a marker of conduction delay. Maximum slope of the APDR curve in BrS patients was significantly steeper than that in control subjects at both the RVOT and the RVA (0.77 ± 0.21 vs. 058 ± 0.14 at RVOT, P = 0.009; 0.98 ± 0.23 vs. 0.62 ± 0.16 at RVA, P = 0.001). The dispersion of maximum slope of the APDR curve between the RVOT and the RVA was also larger in BrS patients than in control subjects. The OAD was significantly longer in BrS patients than in control subjects from the RVOT to RVA and from the RVA to RVOT (from RVOT to RVA: 256 ± 12 vs. 243 ± 7 ms, P = 0.003; from RVA to RVOT: 252 ± 11 vs. 241 ± 9 ms, P = 0.01).ConclusionsAbnormal APDR properties and conduction delay were observed in BrS patients. Both repolarization and depolarization abnormalities are thought to be related to the development of VF in BrS patients.

AB - Aims This study sought to examine the action potential duration restitution (APDR) property and conduction delay in Brugada syndrome (BrS) patients. A steeply sloped APDR curve and conduction delay are known to be important determinants for the occurrence of ventricular fibrillation (VF).Methods and resultsEndocardial monophasic action potential was obtained from 39 BrS patients and 9 control subjects using the contact electrode method. Maximum slopes of the APDR curve were obtained at both the right ventricular outflow tract (RVOT) and the right ventricular apex (RVA). The onset of activation delay (OAD) after premature stimulation was examined as a marker of conduction delay. Maximum slope of the APDR curve in BrS patients was significantly steeper than that in control subjects at both the RVOT and the RVA (0.77 ± 0.21 vs. 058 ± 0.14 at RVOT, P = 0.009; 0.98 ± 0.23 vs. 0.62 ± 0.16 at RVA, P = 0.001). The dispersion of maximum slope of the APDR curve between the RVOT and the RVA was also larger in BrS patients than in control subjects. The OAD was significantly longer in BrS patients than in control subjects from the RVOT to RVA and from the RVA to RVOT (from RVOT to RVA: 256 ± 12 vs. 243 ± 7 ms, P = 0.003; from RVA to RVOT: 252 ± 11 vs. 241 ± 9 ms, P = 0.01).ConclusionsAbnormal APDR properties and conduction delay were observed in BrS patients. Both repolarization and depolarization abnormalities are thought to be related to the development of VF in BrS patients.

KW - Brugada syndrome

KW - Conduction delay

KW - Monophasic action potential duration

KW - Restitution curve

KW - Ventricular fibrillation

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