Aberrant expression of the monocyte/macrophage phenotype in a human T cell line immortalized by HTLV‐I and an adult T cell leukemia/lymphoma cell line

Ho Jong Jeon, Tadaatsu Akagi, Tadashi Yoshino, Kiyoshi Takahashi, Kazuhiko Hayashi, Eisaku Kondo, Ashit Baran Sarker, Norihiro Teramoto, Kotaro Fujiwara, Nobuya Ohara, Kanji Miyamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An HTLV‐I‐immortalized human T cell line (JP‐2), a N‐methyl‐N′‐nitro‐N‐nitrosoguanidine‐treated JP‐2 line (JP‐2T), and an adult T cell leukemia cell line (ATL‐1T) were examined morphologically and phenotypically. All of these cell lines expressed some T cell markers, including CD4, and showed rearrangement of T cell receptor (TCR) genes, but they lacked CD3 and TCR antigens and expressed some myelomonocytic markers (CD68, HL‐21, CD15, CD16). JP‐2 cells grew in suspension, but JP‐2T and ATL‐1T cells, which mostly adhered to the surface of culture vessels, showed macrophage‐like morphological features and expressed more monocyte/macrophage markers (lysozyme, α1‐antitrypsin) and fibronectin. ATL‐1T cells transplanted into SCID mice lost the macrophage features. These results suggest that HTLV‐I infected T cells can express some macrophage features and that these cells may provide a model that will be useful in elucidating the phenotypic variability of T cell lymphomas.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalPathology International
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 1994

Keywords

  • HTLV‐I
  • cultured cells
  • histiocyte
  • immunohisto‐chemistry
  • leukemia/lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Aberrant expression of the monocyte/macrophage phenotype in a human T cell line immortalized by HTLV‐I and an adult T cell leukemia/lymphoma cell line'. Together they form a unique fingerprint.

  • Cite this