Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma

Akira Shimada, Goshi Shiota, Hironori Miyata, Toshio Kamahora, Hironaka Kawasaki, Kazuo Shiraki, Shigeo Hino, Tadashi Terada

Research output: Contribution to journalArticle

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Abstract

We immunohistochemically analyzed the expression of double-stranded RNA- dependent protein kinase (PKR) using a monoclonal antibody, 71/10. Test samples included 64 human liver biopsies and 25 liver sections of rats inoculated with diethylnitrosamine. The PKR signals in human fatty livers and normal rat livers were minimum. Scoring signal intensity from 0-4, the average scores of chronic active (14 cases) and chronic persistent (6 cases) hepatitis associated with hepatitis virus C (HCV) were 2.8 and 2.0, respectively (P = 0.038). The stained cells were significantly more abundant in the periportal than centrilobular regions for both chronic active and persistent hepatitis (P

Original languageEnglish
Pages (from-to)4434-4438
Number of pages5
JournalCancer Research
Volume58
Issue number19
Publication statusPublished - Oct 1 1998
Externally publishedYes

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eIF-2 Kinase
Double-Stranded RNA
Chronic Hepatitis
Hepatocytes
Hepatocellular Carcinoma
Liver
Diethylnitrosamine
Fatty Liver
Hepacivirus
Hepatitis
Monoclonal Antibodies
Biopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. / Shimada, Akira; Shiota, Goshi; Miyata, Hironori; Kamahora, Toshio; Kawasaki, Hironaka; Shiraki, Kazuo; Hino, Shigeo; Terada, Tadashi.

In: Cancer Research, Vol. 58, No. 19, 01.10.1998, p. 4434-4438.

Research output: Contribution to journalArticle

Shimada, A, Shiota, G, Miyata, H, Kamahora, T, Kawasaki, H, Shiraki, K, Hino, S & Terada, T 1998, 'Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma', Cancer Research, vol. 58, no. 19, pp. 4434-4438.
Shimada, Akira ; Shiota, Goshi ; Miyata, Hironori ; Kamahora, Toshio ; Kawasaki, Hironaka ; Shiraki, Kazuo ; Hino, Shigeo ; Terada, Tadashi. / Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. In: Cancer Research. 1998 ; Vol. 58, No. 19. pp. 4434-4438.
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