A Widely Applicable Electrode Sensitive to Basic Drugs Based on Poly(vinyl chloride) Membrane Plasticized with Tricresyl Phosphate

Hiroshi Nakagawa, Masaki Mifune, Yutaka Saito, Hirofumi Suzuki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A plastic membrane ion-selective electrode applicable to many basic drugs has been developed. The electrode developed was constructed with tricresyl phosphate and a poly(vinyl chloride) matrix on a polytetrafluoroethylene film. The electrode showed a near-Nernstian response to chlorpromazine, trihexyphenidyl, imipramine, dibucaine, papaverine, propranolol, tetracaine, trazodone, quinidine and cinnarizine. The determination of 50 to 3000 μg/ml of trazodone hydrochloride in a pH 4.0 acetate buffer solution showed an average recovery of 99.4% (mean standard deviation 0.7%) by direct potentiometry. Inorganic cations and pharmaceutical excipients did not interfere with the determination. Trazodone hydrochloride and trihexyphenidyl hydrochloride in tablets were determined, and the results compared favorably with those obtained by conventional methods.

Original languageEnglish
Pages (from-to)1123-1126
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number6
DOIs
Publication statusPublished - 1993

Keywords

  • basic drugs
  • ion-selective electrode
  • pharmaceutical analysis
  • phosphate
  • poly(vinyl chloride) membrane electrode
  • potentiometry
  • tricresyl

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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