A volumetric study of amygdala in cancer survivors with intrusive recollections

Yutaka Matsuoka, Shigeto Yamawaki, Masatoshi Inagaki, Tatsuo Akechi, Yosuke Uchitomi

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: Intrusive recollections, one of the re-experiencing symptoms of posttraumatic stress disorder (PTSD), frequently occur in cancer survivors rather than the full spectrum of the symptoms of PTSD. Functional neuroimaging studies of PTSD have revealed hyperresponsiveness to threat-related stimuli in the amygdala, but no volumetric studies have ever found alteration in the volume of the amygdala. The aim of the present study was to assess the possibility of structural alteration of the amygdala in cancer survivors with intrusive recollections. Methods: Magnetic resonance imaging volumetric analysis of the amygdala was performed in 35 breast cancer survivors with a history of cancer-related intrusive recollections and 41 control breast cancer survivors who had no such history. The groups were similar in age, height, handedness, alcohol consumption, and medical characteristics except for past major depressive disorder. Results: The total volume of the amygdala was significantly smaller in subjects with a history of intrusive recollections as compared with the control subjects. This finding continued to be significant after controlling for age, height, and major depressive disorder. Conclusions: These results suggest a difference in volume of the amygdala of cancer survivors according to whether they have had cancer-related intrusive recollections.

Original languageEnglish
Pages (from-to)736-743
Number of pages8
JournalBiological Psychiatry
Volume54
Issue number7
DOIs
Publication statusPublished - Oct 1 2003
Externally publishedYes

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Amygdala
Post-Traumatic Stress Disorders
Neoplasms
Major Depressive Disorder
Breast Neoplasms
Functional Neuroimaging
Functional Laterality
Alcohol Drinking
History
Magnetic Resonance Imaging

Keywords

  • Amygdala
  • Cancer survivors
  • Intrusive recollections
  • MRI volumetry
  • PTSD

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

A volumetric study of amygdala in cancer survivors with intrusive recollections. / Matsuoka, Yutaka; Yamawaki, Shigeto; Inagaki, Masatoshi; Akechi, Tatsuo; Uchitomi, Yosuke.

In: Biological Psychiatry, Vol. 54, No. 7, 01.10.2003, p. 736-743.

Research output: Contribution to journalArticle

Matsuoka, Y, Yamawaki, S, Inagaki, M, Akechi, T & Uchitomi, Y 2003, 'A volumetric study of amygdala in cancer survivors with intrusive recollections', Biological Psychiatry, vol. 54, no. 7, pp. 736-743. https://doi.org/10.1016/S0006-3223(02)01907-8
Matsuoka, Yutaka ; Yamawaki, Shigeto ; Inagaki, Masatoshi ; Akechi, Tatsuo ; Uchitomi, Yosuke. / A volumetric study of amygdala in cancer survivors with intrusive recollections. In: Biological Psychiatry. 2003 ; Vol. 54, No. 7. pp. 736-743.
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