A vesicular transporter that mediates aspartate and glutamate neurotransmission

Takaaki Miyaji, Hiroshi Omote, Yoshinori Moriyama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aspartate, an excitatory amino acid, is known to be stored in synaptic vesicles and exocytosed from some neurons to perform aspartergic neurotransmission. Through in vitro reconstitution, we found that sialin, a lysosomal sialic acid exporter, is responsible for the vesicular storage of aspartate in hippocampal neurons and pinealocytes. Mutations found in Salla disease cause decreased aspartate transport activity without affecting sialic acid transport. Thus, sialin is a multifunctional transporter. It is possible that people with Salla disease lose the ability of aspartergic neurotransmission, and this could explain why Salla disease involves severe neurological defects.

Original languageEnglish
Pages (from-to)1783-1785
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 19 2010

Keywords

  • Aspartate
  • Neurotransmission
  • Salla disease
  • Veicular glutamate transporter
  • Vesicular excitatory amino acid transporter

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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