A very rare case of breast cancer in a female-to-male transsexual

Yuko Katayama, Takayuki Motoki, Satoko Watanabe, Saiga Miho, Yoshihiro Kimata, Junji Matsuoka, Hiroyoshi Doihara, Yuzaburo Namba

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalBreast Cancer
DOIs
Publication statusAccepted/In press - Dec 11 2015

Fingerprint

Mastectomy
Breast Neoplasms
Testosterone
Sex Reassignment Surgery
Androgen Receptors
Gonadal Steroid Hormones
Ovariectomy
Hysterectomy
Estrogen Receptors
Hormones
Incidence
Neoplasms

Keywords

  • Breast cancer
  • Hormone therapy
  • Transsexual

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

A very rare case of breast cancer in a female-to-male transsexual. / Katayama, Yuko; Motoki, Takayuki; Watanabe, Satoko; Miho, Saiga; Kimata, Yoshihiro; Matsuoka, Junji; Doihara, Hiroyoshi; Namba, Yuzaburo.

In: Breast Cancer, 11.12.2015, p. 1-6.

Research output: Contribution to journalArticle

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