A very rare case of breast cancer in a female-to-male transsexual

Yuko Katayama, Takayuki Motoki, Satoko Watanabe, Saiga Miho, Yoshihiro Kimata, Junji Matsuoka, Hiroyoshi Doihara, Yuzaburo Nanba

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.

Original languageEnglish
Pages (from-to)939-944
Number of pages6
JournalBreast Cancer
Volume23
Issue number6
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • Breast cancer
  • Hormone therapy
  • Transsexual

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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