A versatile biodegradable polymer with a thermo-reversible/irreversible transition

Fumiaki Tanimoto, Yoshiro Kitamura, Tsutomu Ono, Hidekazu Yoshizawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A versatile biodegradable thermoresponsive polymer was developed. The polymer has succinimide and isopropylasparamide segments and exhibits a phase transition with thermoreversibility that can be controlled by changing the polymer composition. With fewer succinimide units, the polymer exhibits the type of thermo-reversible phase transition that is characteristic of poly(N-isopropylacrylamide) (PNIPAAm). The polymer with a higher proportion of succinimide units exhibits a thermo-irreversible phase transition, resulting in the formation of nanospheres that are stable below the transition temperature. The stable nanospheres are generated by dehydration and subsequent conformational stabilization through an interaction between imide rings. This thermoirreversible phase transition in water provides a simple, oil-free preparation of biodegradable nanospheres.

Original languageEnglish
Pages (from-to)606-610
Number of pages5
JournalACS Applied Materials and Interfaces
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 24 2010

Fingerprint

Biodegradable polymers
Nanospheres
Polymers
Phase transitions
Imides
Dehydration
Superconducting transition temperature
Oils
Stabilization
Water
Chemical analysis
succinimide

Keywords

  • Biodegradable nanosphere
  • Irreversible phase transition
  • Poly(aspartic acid)
  • Poly(succinimide)
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

A versatile biodegradable polymer with a thermo-reversible/irreversible transition. / Tanimoto, Fumiaki; Kitamura, Yoshiro; Ono, Tsutomu; Yoshizawa, Hidekazu.

In: ACS Applied Materials and Interfaces, Vol. 2, No. 3, 24.03.2010, p. 606-610.

Research output: Contribution to journalArticle

Tanimoto, Fumiaki ; Kitamura, Yoshiro ; Ono, Tsutomu ; Yoshizawa, Hidekazu. / A versatile biodegradable polymer with a thermo-reversible/irreversible transition. In: ACS Applied Materials and Interfaces. 2010 ; Vol. 2, No. 3. pp. 606-610.
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