TY - JOUR
T1 - A Unique Recurrent Stroke Case due to Bilateral Vertebral Artery Dissection with Familial Hirschsprung Disease
AU - Sato, Kota
AU - Sasaki, Ryo
AU - Ohta, Yasuyuki
AU - Takemoto, Mami
AU - Hishikawa, Nozomi
AU - Yamashita, Toru
AU - Abe, Koji
N1 - Funding Information:
We are grateful to Dr Koichiro Yoshimaru, MD, PhD (Department of Pediatric Surgery, Kyushu University, Fukuoka, Japan) for their important suggestions related to colon pathology. The authors state that they have no conflicts of interest.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8
Y1 - 2019/8
N2 - Vertebral artery (VA) dissection is one major cause of brain infarction in young and middle-aged adults. Risk factors for VA dissection are hypertension, diabetes mellitus, hyperlipidemia, trauma, and genetic factors. A 32-year-old man with familial Hirschsprung disease at the age of 2 presented cerebellar ischemic stroke due to bilateral VA dissections. A stroke recurred within 17 days despite oral dual antiplatelet therapy. Bilateral VA dissections and recurrent dissections are related to genetic mutations associated with connective tissue diseases. A part of familial Hirschsprung disease has genetic factors in common with cerebrovascular disease. There may be a common genetic background between his VA dissection and Hirschsprung disease.
AB - Vertebral artery (VA) dissection is one major cause of brain infarction in young and middle-aged adults. Risk factors for VA dissection are hypertension, diabetes mellitus, hyperlipidemia, trauma, and genetic factors. A 32-year-old man with familial Hirschsprung disease at the age of 2 presented cerebellar ischemic stroke due to bilateral VA dissections. A stroke recurred within 17 days despite oral dual antiplatelet therapy. Bilateral VA dissections and recurrent dissections are related to genetic mutations associated with connective tissue diseases. A part of familial Hirschsprung disease has genetic factors in common with cerebrovascular disease. There may be a common genetic background between his VA dissection and Hirschsprung disease.
KW - Bilateral vertebral arteries
KW - Dual antiplatelet therapy
KW - Familial Hirschsprung disease
KW - Fibromuscular dysplasia
KW - Vertebral artery dissection
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U2 - 10.1016/j.jstrokecerebrovasdis.2019.04.035
DO - 10.1016/j.jstrokecerebrovasdis.2019.04.035
M3 - Article
C2 - 31129106
AN - SCOPUS:85065860294
SN - 1052-3057
VL - 28
SP - e113-e115
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 8
ER -
