A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation

Ryo Sasaki, Yoshio Omote, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Koji Abe

Research output: Contribution to journalArticlepeer-review

Abstract

Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where mild accumulation of helper T cells and neutrophils in the dermis histologically are observed. Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion. Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a possible link in the pathogenesis.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalNeurology Asia
Volume25
Issue number3
Publication statusPublished - Sep 2020

Keywords

  • Corticosteroid
  • Helper T cell
  • Leukoencephalopathy
  • Palmoplantar pustulosis
  • Pathological feature

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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