A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation

Ryo Sasaki; Yosio Omote; Koh Tadokoro; Namiko Matsumoto; Emi Nomura; Mami Takemoto; Nozomi Hishikawa; Toru Yamashita; Yasuyuki Ohta; Koji Abe

A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation

Ryo Sasaki, Yosio Omote, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Koji Abe

Research output: Contribution to journal › Article › peer-review

Abstract

Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where mild accumulation of helper T cells and neutrophils in the dermis histologically are observed. Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion. Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a possible link in the pathogenesis.

Original language	English
Pages (from-to)	415-418
Number of pages	4
Journal	Neurology Asia
Volume	25
Issue number	3
Publication status	Published - Sept 2020

Keywords

Corticosteroid
Helper T cell
Leukoencephalopathy
Palmoplantar pustulosis
Pathological feature

ASJC Scopus subject areas

Neurology
Clinical Neurology

Cite this

@article{d183d183187f4f6e85c2d6f63d9f358e,

title = "A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation",

abstract = "Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where mild accumulation of helper T cells and neutrophils in the dermis histologically are observed. Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion. Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a possible link in the pathogenesis.",

keywords = "Corticosteroid, Helper T cell, Leukoencephalopathy, Palmoplantar pustulosis, Pathological feature",

author = "Ryo Sasaki and Yosio Omote and Koh Tadokoro and Namiko Matsumoto and Emi Nomura and Mami Takemoto and Nozomi Hishikawa and Toru Yamashita and Yasuyuki Ohta and Koji Abe",

note = "Funding Information: Financial support: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 17H0419611, (C) 15K0931607, 17H0975609, and 17K1082709, and by Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from the Japan Agency for Medical Research and Development 7211800049, 7211800130, and 7211700121. Publisher Copyright: {\textcopyright} 2020, ASEAN Neurological Association. All rights reserved.",

year = "2020",

month = sep,

language = "English",

volume = "25",

pages = "415--418",

journal = "Neurology Asia",

issn = "1823-6138",

publisher = "ASEAN Neurological Association",

number = "3",

}

TY - JOUR

T1 - A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation

AU - Sasaki, Ryo

AU - Omote, Yosio

AU - Tadokoro, Koh

AU - Matsumoto, Namiko

AU - Nomura, Emi

AU - Takemoto, Mami

AU - Hishikawa, Nozomi

AU - Yamashita, Toru

AU - Ohta, Yasuyuki

AU - Abe, Koji

N1 - Funding Information: Financial support: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 17H0419611, (C) 15K0931607, 17H0975609, and 17K1082709, and by Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from the Japan Agency for Medical Research and Development 7211800049, 7211800130, and 7211700121. Publisher Copyright: © 2020, ASEAN Neurological Association. All rights reserved.

PY - 2020/9

Y1 - 2020/9

N2 - Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where mild accumulation of helper T cells and neutrophils in the dermis histologically are observed. Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion. Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a possible link in the pathogenesis.

AB - Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where mild accumulation of helper T cells and neutrophils in the dermis histologically are observed. Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion. Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a possible link in the pathogenesis.

KW - Corticosteroid

KW - Helper T cell

KW - Leukoencephalopathy

KW - Palmoplantar pustulosis

KW - Pathological feature

UR - http://www.scopus.com/inward/record.url?scp=85091661895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85091661895&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85091661895

SN - 1823-6138

VL - 25

SP - 415

EP - 418

JO - Neurology Asia

JF - Neurology Asia

IS - 3

ER -

A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this