A unique case with oral dyskinesia, chorea, ataxia, and mild cognitive impairment with caudate atrophy and characteristic brain calcifications

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The authors report a man who developed oral dyskinesia at 46 years of age, followed by slowly progressive choreic movement and mild cognitive impairment over 20 years. He showed caudate atrophy and four types of intracranial calcification in the hippocampus (dot-like), cerebellar white matter (vague-mass), occipi-tal cortices (laminar), and cerebral white matter (linear). Linear-calcification in the corona radiata seems to be deposition along small veins, which may be related to the white matter changes and to the decreased regional cerebral blood flow in the frontal and parietal lobes. The present case shows a slowly progressive disease with caudate atrophy and characteristic brain calcifications.

Original languageEnglish
Pages (from-to)2399-2402
Number of pages4
JournalInternal Medicine
Issue number16
Publication statusPublished - Jan 1 2018



  • Choreic movement
  • Cognitive impairment
  • Intracranial calcification
  • Oral dyskinesia
  • Truncal ataxia

ASJC Scopus subject areas

  • Internal Medicine

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