A unique case of encephalopathy with an elevated igg-4 and extremely high interleukin-6 level and delayed myelodysplastic syndrome

Namiko Matsumoto, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yosio Omote, Mami Takemoto, Toru Yamashita, Kohei Taniguchi, Koji Abe

Research output: Contribution to journalArticlepeer-review

Abstract

We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right supraclavicular lymph node showed the infiltration of inflammatory cells positive for IgG, IgG4 and IL-6. Prednisolone and azathioprine administered under suspicion of IgG4-related disease (IgG4-RD) or multicentric Castleman’s disease (MCD) successfully remitted the symptoms. However, he developed myelodysplastic syndrome (MDS) and died 18 months later. The extremely high IL-6 may have been related to the rare neurological manifestations and development of MDS in the present case.

Original languageEnglish
Pages (from-to)2125-2128
Number of pages4
JournalInternal Medicine
Volume60
Issue number13
DOIs
Publication statusPublished - 2021

Keywords

  • Encephalopathy
  • IgG4 related disease
  • Interleukin-6
  • Multicentric Castleman’s disease

ASJC Scopus subject areas

  • Internal Medicine

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