A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols

Isao Kadota, Yueqing Hu, Garrick K. Packard, Scott D. Rychnovsky

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Polyene macrolide antibiotics are naturally occurring antifungal agents. Members of this class include amphotericin B, which has been used widely to treat systemic fungal infections. A general synthetic strategy has been devised to prepare polyol chains associated with the polyene macrolides. Cyanohydrin acetonide alkylations were used to assemble the carbon skeleton, and a simple modification of the strategy allowed an advanced intermediate to be converted to either the candidin polyol or the nystatin polyol. The candidin polyol was further elaborated to a protected candidin aglycone. This strategy will be applicable to other members of the polyene macrolide natural products.

Original languageEnglish
Pages (from-to)11992-11995
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number33
DOIs
Publication statusPublished - Aug 17 2004
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols'. Together they form a unique fingerprint.

Cite this