A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols

Isao Kadota; Yueqing Hu; Garrick K. Packard; Scott D. Rychnovsky

doi:10.1073/pnas.0401552101

A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols

Isao Kadota, Yueqing Hu, Garrick K. Packard, Scott D. Rychnovsky

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Polyene macrolide antibiotics are naturally occurring antifungal agents. Members of this class include amphotericin B, which has been used widely to treat systemic fungal infections. A general synthetic strategy has been devised to prepare polyol chains associated with the polyene macrolides. Cyanohydrin acetonide alkylations were used to assemble the carbon skeleton, and a simple modification of the strategy allowed an advanced intermediate to be converted to either the candidin polyol or the nystatin polyol. The candidin polyol was further elaborated to a protected candidin aglycone. This strategy will be applicable to other members of the polyene macrolide natural products.

Original language	English
Pages (from-to)	11992-11995
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	101
Issue number	33
DOIs	https://doi.org/10.1073/pnas.0401552101
Publication status	Published - Aug 17 2004

ASJC Scopus subject areas

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Kadota, I., Hu, Y., Packard, G. K., & Rychnovsky, S. D. (2004). A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 11992-11995. https://doi.org/10.1073/pnas.0401552101

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