A theranostic approach based on the use of a dual boron/Gd agent to improve the efficacy of Boron Neutron Capture Therapy in the lung cancer treatment

Diego Alberti, Nicoletta Protti, Antonio Toppino, Annamaria Deagostino, Stefania Lanzardo, Silva Bortolussi, Saverio Altieri, Claudia Voena, Roberto Chiarle, Simonetta Geninatti Crich, Silvio Aime

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

This study aims at developing an innovative theranostic approach for lung tumor and metastases treatment, based on Boron Neutron Capture Therapy (BNCT). It relies on to the use of low density lipoproteins (LDL) as carriers able to maximize the selective uptake of boron atoms in tumor cells and, at the same time, to quantify the in vivo boron distribution by magnetic resonance imaging (MRI). Tumor cells uptake was initially assessed by ICP-MS and MRI on four types of tumor (TUBO, B16-F10, MCF-7, A549) and one healthy (N-MUG) cell lines. Lung metastases were generated by intravenous injection of a Her2. + breast cancer cell line (i.e. TUBO) in BALB/c mice and transgenic EML4-ALK mice were used as primary tumor model. After neutron irradiation, tumor growth was followed for 30-40. days by MRI. Tumor masses of boron treated mice increased markedly slowly than the control group.

Original languageEnglish
Pages (from-to)741-750
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume11
Issue number3
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Boron Neutron Capture Therapy (BNCT)
  • Carboranes
  • Low density lipoproteins (LDL)
  • MRI
  • Theranostic agents

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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