A tertiary sulfonium compound, dimethylsulfoniopropionate in green sea algae, completely suppresses crucial ehrlich ascites carcinoma in mice

Kenji Nakajima, Satomi Tsujiwaki, Yoshiki Nakajima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aim: Dimethylsulfoniopropionate (DMSP) has been intensively studied in bacteria, plankton, algae and salt-resistant plants to investigate its metabolism and fate in the atmosphere. However, its effects on diseased terrestrial animals have not yet been examined. We have found that DMSP exerts a great healing effect for a variety of inflammatory disorders in rodents. In the present study, effects of single and high concentration of DMSP on terrible Ehrlich ascites carcinoma (EAC) bearing-mice with unavoidable-rapid death were examined. Results: We found that high concentration of DMSP completely suppresses acute EAC, which has never been eradicated, and accumulates large amounts of activated macrophages with no inflammation on various viscera in the peritoneal cavity of normal mice. Conclusion: These results show that DMSP is a new and potent anticancer compound with no side-effects, most likely playing a vital role for cancer immune therapy.

Original languageEnglish
Pages (from-to)4045-4050
Number of pages6
JournalAnticancer research
Volume34
Issue number8
Publication statusPublished - Aug 1 2014

Fingerprint

Sulfonium Compounds
Chlorophyta
Ascites
Oceans and Seas
Carcinoma
Salt-Tolerant Plants
Plankton
Animal Diseases
Viscera
Peritoneal Cavity
Atmosphere
Rodentia
Macrophages
dimethylpropiothetin
Inflammation
Bacteria

Keywords

  • Anti-cancer effects
  • Ascites fluid
  • Dimethylsulfoniopropionate
  • Ehrlich ascites carcinoma
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A tertiary sulfonium compound, dimethylsulfoniopropionate in green sea algae, completely suppresses crucial ehrlich ascites carcinoma in mice. / Nakajima, Kenji; Tsujiwaki, Satomi; Nakajima, Yoshiki.

In: Anticancer research, Vol. 34, No. 8, 01.08.2014, p. 4045-4050.

Research output: Contribution to journalArticle

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