Abstract
Background/Aim: Dimethylsulfoniopropionate (DMSP) has been intensively studied in bacteria, plankton, algae and salt-resistant plants to investigate its metabolism and fate in the atmosphere. However, its effects on diseased terrestrial animals have not yet been examined. We have found that DMSP exerts a great healing effect for a variety of inflammatory disorders in rodents. In the present study, effects of single and high concentration of DMSP on terrible Ehrlich ascites carcinoma (EAC) bearing-mice with unavoidable-rapid death were examined. Results: We found that high concentration of DMSP completely suppresses acute EAC, which has never been eradicated, and accumulates large amounts of activated macrophages with no inflammation on various viscera in the peritoneal cavity of normal mice. Conclusion: These results show that DMSP is a new and potent anticancer compound with no side-effects, most likely playing a vital role for cancer immune therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 4045-4050 |
| Number of pages | 6 |
| Journal | Anticancer research |
| Volume | 34 |
| Issue number | 8 |
| Publication status | Published - Aug 1 2014 |
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Keywords
- Anti-cancer effects
- Ascites fluid
- Dimethylsulfoniopropionate
- Ehrlich ascites carcinoma
- Toxicity
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
A tertiary sulfonium compound, dimethylsulfoniopropionate in green sea algae, completely suppresses crucial ehrlich ascites carcinoma in mice. / Nakajima, Kenji; Tsujiwaki, Satomi; Nakajima, Yoshiki.
In: Anticancer research, Vol. 34, No. 8, 01.08.2014, p. 4045-4050.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A tertiary sulfonium compound, dimethylsulfoniopropionate in green sea algae, completely suppresses crucial ehrlich ascites carcinoma in mice
AU - Nakajima, Kenji
AU - Tsujiwaki, Satomi
AU - Nakajima, Yoshiki
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Background/Aim: Dimethylsulfoniopropionate (DMSP) has been intensively studied in bacteria, plankton, algae and salt-resistant plants to investigate its metabolism and fate in the atmosphere. However, its effects on diseased terrestrial animals have not yet been examined. We have found that DMSP exerts a great healing effect for a variety of inflammatory disorders in rodents. In the present study, effects of single and high concentration of DMSP on terrible Ehrlich ascites carcinoma (EAC) bearing-mice with unavoidable-rapid death were examined. Results: We found that high concentration of DMSP completely suppresses acute EAC, which has never been eradicated, and accumulates large amounts of activated macrophages with no inflammation on various viscera in the peritoneal cavity of normal mice. Conclusion: These results show that DMSP is a new and potent anticancer compound with no side-effects, most likely playing a vital role for cancer immune therapy.
AB - Background/Aim: Dimethylsulfoniopropionate (DMSP) has been intensively studied in bacteria, plankton, algae and salt-resistant plants to investigate its metabolism and fate in the atmosphere. However, its effects on diseased terrestrial animals have not yet been examined. We have found that DMSP exerts a great healing effect for a variety of inflammatory disorders in rodents. In the present study, effects of single and high concentration of DMSP on terrible Ehrlich ascites carcinoma (EAC) bearing-mice with unavoidable-rapid death were examined. Results: We found that high concentration of DMSP completely suppresses acute EAC, which has never been eradicated, and accumulates large amounts of activated macrophages with no inflammation on various viscera in the peritoneal cavity of normal mice. Conclusion: These results show that DMSP is a new and potent anticancer compound with no side-effects, most likely playing a vital role for cancer immune therapy.
KW - Anti-cancer effects
KW - Ascites fluid
KW - Dimethylsulfoniopropionate
KW - Ehrlich ascites carcinoma
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=84908691694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908691694&partnerID=8YFLogxK
M3 - Article
C2 - 25075028
AN - SCOPUS:84908691694
VL - 34
SP - 4045
EP - 4050
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 8
ER -