A taxane with a novel 9α,13α-oxygen bridge from Taxus cuspidata needles

Man Li Zhang, Qing Wen Shi, Mei Dong, Yu Fang Wang, Chang Hong Huo, Yu Cheng Gu, Bin Cong, Hiromasa Kiyota

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A novel taxane with an unprecedented hemiacetal ring between C-13 and C-9 was isolated from the needles of Taxus cuspidata. The structure was characterized as (12αH)-2α,10β-diacetoxy-5α-cinnamoyloxy-9α,13α-epoxytax-4(20)-ene-11β,13β-diol (1). This is the first example of a natural taxane with a C-13 and C-9 oxygen bridge to form an unusual 6/8/6/6-membered ring system.

Original languageEnglish
Pages (from-to)1180-1183
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number7
DOIs
Publication statusPublished - Feb 11 2008

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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