A taxane with a novel 9α,13α-oxygen bridge from Taxus cuspidata needles

Man Li Zhang, Qing Wen Shi, Mei Dong, Yu Fang Wang, Chang Hong Huo, Yu Cheng Gu, Bin Cong, Hiromasa Kiyota

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A novel taxane with an unprecedented hemiacetal ring between C-13 and C-9 was isolated from the needles of Taxus cuspidata. The structure was characterized as (12αH)-2α,10β-diacetoxy-5α-cinnamoyloxy-9α,13α-epoxytax-4(20)-ene-11β,13β-diol (1). This is the first example of a natural taxane with a C-13 and C-9 oxygen bridge to form an unusual 6/8/6/6-membered ring system.

Original languageEnglish
Pages (from-to)1180-1183
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number7
DOIs
Publication statusPublished - Feb 11 2008
Externally publishedYes

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Taxus
Needles
Oxygen
taxane

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A taxane with a novel 9α,13α-oxygen bridge from Taxus cuspidata needles. / Zhang, Man Li; Shi, Qing Wen; Dong, Mei; Wang, Yu Fang; Huo, Chang Hong; Gu, Yu Cheng; Cong, Bin; Kiyota, Hiromasa.

In: Tetrahedron Letters, Vol. 49, No. 7, 11.02.2008, p. 1180-1183.

Research output: Contribution to journalArticle

Zhang, ML, Shi, QW, Dong, M, Wang, YF, Huo, CH, Gu, YC, Cong, B & Kiyota, H 2008, 'A taxane with a novel 9α,13α-oxygen bridge from Taxus cuspidata needles', Tetrahedron Letters, vol. 49, no. 7, pp. 1180-1183. https://doi.org/10.1016/j.tetlet.2007.12.045
Zhang, Man Li ; Shi, Qing Wen ; Dong, Mei ; Wang, Yu Fang ; Huo, Chang Hong ; Gu, Yu Cheng ; Cong, Bin ; Kiyota, Hiromasa. / A taxane with a novel 9α,13α-oxygen bridge from Taxus cuspidata needles. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 7. pp. 1180-1183.
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