A syn-Selective Aza-Aldol Reaction of Boron Aza-Enolates Generated from N-Sulfonyl-1,2,3-Triazoles and 9-BBN-H

Tomoya Miura, Takayuki Nakamuro, Sho Miyakawa, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

A syn-selective aza-aldol reaction of boron aza-enolates, generated from N-sulfonyl-1,2,3-triazoles and 9-BBN-H, is reported. It provides a sequential one-pot procedure for the stereoselective construction of 1,3-amino alcohols, having contiguous stereocenters, starting from terminal alkynes.

Original languageEnglish
Pages (from-to)8732-8735
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number30
DOIs
Publication statusPublished - Jul 18 2016
Externally publishedYes

Keywords

  • aldol reaction
  • boron
  • carbenoids
  • rhodium
  • triazoles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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