A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease

Kyotaro Ohno, Yasuharu Sato, Koh Ichi Ohshima, Katsuyoshi Takata, Tomoko Miyata-Takata, Mai Takeuchi, Yuka Gion, Tomoyasu Tachibana, Yorihisa Orita, Toshihiro Ito, Steven H. Swerdlow, Tadashi Yoshino

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Abstract

We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.

Original languageEnglish
Article number13539
JournalScientific reports
Volume5
DOIs
Publication statusPublished - Aug 27 2015

ASJC Scopus subject areas

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    Ohno, K., Sato, Y., Ohshima, K. I., Takata, K., Miyata-Takata, T., Takeuchi, M., Gion, Y., Tachibana, T., Orita, Y., Ito, T., Swerdlow, S. H., & Yoshino, T. (2015). A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease. Scientific reports, 5, [13539]. https://doi.org/10.1038/srep13539