A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease

Kyotaro Ohno, Yasuharu Sato, Koh Ichi Ohshima, Katsuyoshi Takata, Tomoko Miyata-Takata, Mai Takeuchi, Yuka Gion, Tomoyasu Tachibana, Yorihisa Orita, Toshihiro Ito, Steven H. Swerdlow, Tadashi Yoshino

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p <0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.

Original languageEnglish
Article number13539
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Aug 27 2015

Fingerprint

Lymphoma
Immunoglobulin G
Actins
Cytokines
Interleukin-13
Transforming Growth Factors
Regulatory T-Lymphocytes
Plasma Cells
Interleukin-4
Interleukin-10
Immunoglobulins
Real-Time Polymerase Chain Reaction
Messenger RNA

ASJC Scopus subject areas

  • General

Cite this

A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease. / Ohno, Kyotaro; Sato, Yasuharu; Ohshima, Koh Ichi; Takata, Katsuyoshi; Miyata-Takata, Tomoko; Takeuchi, Mai; Gion, Yuka; Tachibana, Tomoyasu; Orita, Yorihisa; Ito, Toshihiro; Swerdlow, Steven H.; Yoshino, Tadashi.

In: Scientific Reports, Vol. 5, 13539, 27.08.2015.

Research output: Contribution to journalArticle

Ohno, K, Sato, Y, Ohshima, KI, Takata, K, Miyata-Takata, T, Takeuchi, M, Gion, Y, Tachibana, T, Orita, Y, Ito, T, Swerdlow, SH & Yoshino, T 2015, 'A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease', Scientific Reports, vol. 5, 13539. https://doi.org/10.1038/srep13539
Ohno, Kyotaro ; Sato, Yasuharu ; Ohshima, Koh Ichi ; Takata, Katsuyoshi ; Miyata-Takata, Tomoko ; Takeuchi, Mai ; Gion, Yuka ; Tachibana, Tomoyasu ; Orita, Yorihisa ; Ito, Toshihiro ; Swerdlow, Steven H. ; Yoshino, Tadashi. / A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease. In: Scientific Reports. 2015 ; Vol. 5.
@article{91614f37fdb046f79cc77341cfd812f1,
title = "A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease",
abstract = "We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p <0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.",
author = "Kyotaro Ohno and Yasuharu Sato and Ohshima, {Koh Ichi} and Katsuyoshi Takata and Tomoko Miyata-Takata and Mai Takeuchi and Yuka Gion and Tomoyasu Tachibana and Yorihisa Orita and Toshihiro Ito and Swerdlow, {Steven H.} and Tadashi Yoshino",
year = "2015",
month = "8",
day = "27",
doi = "10.1038/srep13539",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease

AU - Ohno, Kyotaro

AU - Sato, Yasuharu

AU - Ohshima, Koh Ichi

AU - Takata, Katsuyoshi

AU - Miyata-Takata, Tomoko

AU - Takeuchi, Mai

AU - Gion, Yuka

AU - Tachibana, Tomoyasu

AU - Orita, Yorihisa

AU - Ito, Toshihiro

AU - Swerdlow, Steven H.

AU - Yoshino, Tadashi

PY - 2015/8/27

Y1 - 2015/8/27

N2 - We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p <0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.

AB - We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p <0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84940489339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940489339&partnerID=8YFLogxK

U2 - 10.1038/srep13539

DO - 10.1038/srep13539

M3 - Article

C2 - 26311608

AN - SCOPUS:84940489339

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 13539

ER -