A Study to Determine the Optimum Antigens for the Serodiagnosis of Helicobacter Pylori Infection in Japanese Patients and the Association with IgG Subclass and Gastric Cancer

Masahide Kita, Susumu Take, Hiroyuki Okada, Osamu Matsushita, Kenji Yokota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Atrophic gastritis is caused by Helicobacter pylori infection, and is involved in gastric cancer. In this study, we investigated the association with total IgG and IgG subclass antibodies using several strains isolated from Japanese in H. pylori positive and negative individuals, and gastric atrophy using measuring pepsinogen I and II levels. We found that total IgG antibody measurement using typical Japanese genotype as an antigen was available for diagnosis of H. pylori infection, whereas IgG1 and IgG2 antibodies were not for diagnosis. Furthermore, the IgG1/G2 ratio was elevated in a patient with gastric cancer. The accuracy of serodiagnosis of H. pylori infection may increase when the optimal antigens are used, and measurement IgG subclass may provide additional prediction of gastric cancer.

Original languageEnglish
Pages (from-to)180-186
Number of pages7
JournalRinsho byori. The Japanese journal of clinical pathology
Volume63
Issue number2
Publication statusPublished - Feb 1 2015
Externally publishedYes

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Helicobacter Infections
Serologic Tests
Helicobacter pylori
Stomach Neoplasms
Immunoglobulin G
Antigens
Antibodies
Pepsinogen C
Pepsinogen A
Atrophic Gastritis
Atrophy
Stomach
Genotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Atrophic gastritis is caused by Helicobacter pylori infection, and is involved in gastric cancer. In this study, we investigated the association with total IgG and IgG subclass antibodies using several strains isolated from Japanese in H. pylori positive and negative individuals, and gastric atrophy using measuring pepsinogen I and II levels. We found that total IgG antibody measurement using typical Japanese genotype as an antigen was available for diagnosis of H. pylori infection, whereas IgG1 and IgG2 antibodies were not for diagnosis. Furthermore, the IgG1/G2 ratio was elevated in a patient with gastric cancer. The accuracy of serodiagnosis of H. pylori infection may increase when the optimal antigens are used, and measurement IgG subclass may provide additional prediction of gastric cancer.",
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