A study of the hydrophilic cellulose matrix: Effect of indomethacin and a water-soluble additive on swelling properties

Suwannee P. Panomsuk, Tomomi Hatanaka, Tetsuya Aiba, Kazunori Katayama, Tamotsu Koizumi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A swelling measurement device was designed to observe the axial swelling direction of a matrix containing various types of hydrophilic cellulose derivatives (methylcellulose, hydroxypropylmethylcellulose and hydroxypropylcellulose). The effect of indomethacin and lactose on the swelling properties was also studied. The maximum swelling index and the apparent diffusion coefficient of water in the matrix, calculated from the swelling data, were used to describe the swelling properties of the matrix, reflecting the matrix integrity. The results showed that hydroxypropylcellulose produced a matrix with a high integrity. Indomethacin and lactose changed the swelling properties of the hydrophilic cellulose matrices in this study.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume126
Issue number1-2
DOIs
Publication statusPublished - Dec 29 1995
Externally publishedYes

Keywords

  • Apparent diffusion coefficient
  • Hydrophilic cellulose matrix
  • Indomethacin
  • Mathematical model
  • Maximum swelling index
  • Swelling properties

ASJC Scopus subject areas

  • Pharmaceutical Science

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