TY - JOUR
T1 - A Study of the Hydrophilic Cellulose Matrix
T2 - Effect of Indomethacin and a Water-Soluble Additive on Release Mechanisms
AU - Panomsuk, Suwannee P.
AU - Hatanaka, Tomomi
AU - Aiba, Tetsuya
AU - Katayama, Kazunori
AU - Koizum, Tamotsu
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - The release profile of indomethacin (IM) from a direct compressible matrix containing three hydrophilic cellulose derivatives, methylcellulose (MC25 and MC50), hydroxypropylcellulose (HPC140), and hydroxypropylmethylcellu-lose (HPMC50) was studied. The drug release profile was affected by matrix size, polymer type, drug: polymer ratio and water soluble additive (lactose). An IM zero-order release matrix can be obtained by mixture and direct compression with MC50, HPMC50 and HPC140. The release rate from the MC50 and HPC140 matrix can be modified by replacing MC50 or HPC140 with MC25, and a zero-order release could be obtained even when the amount of replacement with MC25 is up to 35 and 45%, respectively. Lactose up to 10% slightly affected the release profile. IM released from this kind of matrix by a zero-order rate seems to be controlled by the swelling and relaxation of the polymer.
AB - The release profile of indomethacin (IM) from a direct compressible matrix containing three hydrophilic cellulose derivatives, methylcellulose (MC25 and MC50), hydroxypropylcellulose (HPC140), and hydroxypropylmethylcellu-lose (HPMC50) was studied. The drug release profile was affected by matrix size, polymer type, drug: polymer ratio and water soluble additive (lactose). An IM zero-order release matrix can be obtained by mixture and direct compression with MC50, HPMC50 and HPC140. The release rate from the MC50 and HPC140 matrix can be modified by replacing MC50 or HPC140 with MC25, and a zero-order release could be obtained even when the amount of replacement with MC25 is up to 35 and 45%, respectively. Lactose up to 10% slightly affected the release profile. IM released from this kind of matrix by a zero-order rate seems to be controlled by the swelling and relaxation of the polymer.
KW - drug release mechanism
KW - hydrophilic cellulose matrix
KW - indomethacin
KW - release profile
KW - water soluble additive
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U2 - 10.1248/cpb.43.994
DO - 10.1248/cpb.43.994
M3 - Article
AN - SCOPUS:0029037789
VL - 43
SP - 994
EP - 999
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 6
ER -