A Study of the Hydrophilic Cellulose Matrix: Effect of Indomethacin and a Water-Soluble Additive on Release Mechanisms

Suwannee P. Panomsuk, Tomomi Hatanaka, Tetsuya Aiba, Kazunori Katayama, Tamotsu Koizum

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The release profile of indomethacin (IM) from a direct compressible matrix containing three hydrophilic cellulose derivatives, methylcellulose (MC25 and MC50), hydroxypropylcellulose (HPC140), and hydroxypropylmethylcellu-lose (HPMC50) was studied. The drug release profile was affected by matrix size, polymer type, drug: polymer ratio and water soluble additive (lactose). An IM zero-order release matrix can be obtained by mixture and direct compression with MC50, HPMC50 and HPC140. The release rate from the MC50 and HPC140 matrix can be modified by replacing MC50 or HPC140 with MC25, and a zero-order release could be obtained even when the amount of replacement with MC25 is up to 35 and 45%, respectively. Lactose up to 10% slightly affected the release profile. IM released from this kind of matrix by a zero-order rate seems to be controlled by the swelling and relaxation of the polymer.

Original languageEnglish
Pages (from-to)994-999
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume43
Issue number6
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Keywords

  • drug release mechanism
  • hydrophilic cellulose matrix
  • indomethacin
  • release profile
  • water soluble additive

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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