Abstract
The swelling properties of hydrophilic cellulose matrices were studied using three drugs having different water solubility: indomethacin, theophylline, and mannitol. Two swelling parameters: maximum swelling index (V) and the apparent diffusion coefficient of water in the matrix (D(w)), were calculated from the swelling data and were used to describe structures and properties of the swollen matrices. The V value indicates the swelling extent as well as the capacity of maintaining the matrix shape, whereas D(w) represents the swelling rate that also reflects the structural resistance of the polymer network against the movement of water molecules. The results show that both polymers and incorporated drugs influence the swelling properties of the matrices. Polymers that contain more hydroxypropoxyl group produce matrices with high integrity, even in the presence of drugs. V values indicated that the capacity of the matrices to maintain their shape depends on polymer (i.e., the swelling part). The effect of drug solubility can be seen from D(w) values. For a highly water-soluble drug, the structural resistance of the swollen matrices is mainly governed by the drug. In contrast, this is primarily influenced by the polymer in the case of drugs that are slightly or poorly water soluble.
| Original language | English |
|---|---|
| Pages (from-to) | 1039-1042 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 44 |
| Issue number | 5 |
| Publication status | Published - May 1996 |
| Externally published | Yes |
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Keywords
- apparent diffusion coefficient
- hydrophilic cellulose matrix
- maximum swelling index
- swelling property
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
A study of the hydrophilic cellulose matrix : Effect of drugs on swelling properties. / Panomsuk, Suwannee P.; Hatanaka, Tomomi; Aiba, Tetsuya; Katayama, Kazunori; Koizumi, Tamotsu.
In: Chemical and Pharmaceutical Bulletin, Vol. 44, No. 5, 05.1996, p. 1039-1042.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A study of the hydrophilic cellulose matrix
T2 - Effect of drugs on swelling properties
AU - Panomsuk, Suwannee P.
AU - Hatanaka, Tomomi
AU - Aiba, Tetsuya
AU - Katayama, Kazunori
AU - Koizumi, Tamotsu
PY - 1996/5
Y1 - 1996/5
N2 - The swelling properties of hydrophilic cellulose matrices were studied using three drugs having different water solubility: indomethacin, theophylline, and mannitol. Two swelling parameters: maximum swelling index (V) and the apparent diffusion coefficient of water in the matrix (D(w)), were calculated from the swelling data and were used to describe structures and properties of the swollen matrices. The V value indicates the swelling extent as well as the capacity of maintaining the matrix shape, whereas D(w) represents the swelling rate that also reflects the structural resistance of the polymer network against the movement of water molecules. The results show that both polymers and incorporated drugs influence the swelling properties of the matrices. Polymers that contain more hydroxypropoxyl group produce matrices with high integrity, even in the presence of drugs. V values indicated that the capacity of the matrices to maintain their shape depends on polymer (i.e., the swelling part). The effect of drug solubility can be seen from D(w) values. For a highly water-soluble drug, the structural resistance of the swollen matrices is mainly governed by the drug. In contrast, this is primarily influenced by the polymer in the case of drugs that are slightly or poorly water soluble.
AB - The swelling properties of hydrophilic cellulose matrices were studied using three drugs having different water solubility: indomethacin, theophylline, and mannitol. Two swelling parameters: maximum swelling index (V) and the apparent diffusion coefficient of water in the matrix (D(w)), were calculated from the swelling data and were used to describe structures and properties of the swollen matrices. The V value indicates the swelling extent as well as the capacity of maintaining the matrix shape, whereas D(w) represents the swelling rate that also reflects the structural resistance of the polymer network against the movement of water molecules. The results show that both polymers and incorporated drugs influence the swelling properties of the matrices. Polymers that contain more hydroxypropoxyl group produce matrices with high integrity, even in the presence of drugs. V values indicated that the capacity of the matrices to maintain their shape depends on polymer (i.e., the swelling part). The effect of drug solubility can be seen from D(w) values. For a highly water-soluble drug, the structural resistance of the swollen matrices is mainly governed by the drug. In contrast, this is primarily influenced by the polymer in the case of drugs that are slightly or poorly water soluble.
KW - apparent diffusion coefficient
KW - hydrophilic cellulose matrix
KW - maximum swelling index
KW - swelling property
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M3 - Article
AN - SCOPUS:0029954017
VL - 44
SP - 1039
EP - 1042
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 5
ER -