A study of evaluating specific tissue oxygen saturation values of gastrointestinal tumors by removing adherent substances in oxygen saturation imaging

Keiichiro Nishihara, Keisuke Hori, Takaaki Saito, Toshihiko Omori, Hironori Sunakawa, Tatsunori Minamide, Masayuki Suyama, Yoichi Yamamoto, Yusuke Yoda, Kensuke Shinmura, Hiroaki Ikematsu, Tomonori Yano

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives Oxygen saturation (OS) imaging is a new method of endoscopic imaging that has clinical applications in oncology which can directly measure tissue oxygen saturation (Sto2) of the surface of gastrointestinal tract without any additional drugs or devices. This imaging technology is expected to contribute to research into cancer biology which leads to clinical benefit such as prediction to efficacy of chemotherapy or radiotherapy. However, adherent substances on tumors such as blood and white coating, pose a challenge for accurate measurements of the StO2 values in tumors. The aim of this study was to develop algorithms for discriminating between the tumors and their adherent substances, and to investigate whether it is possible to evaluate the tumor specific StO2 values excluding adherent substances during OS imaging. Methods We plotted areas of tumors and their adherent substances using white-light images of 50 upper digestive tumors: blood (68 plots); reddish tumor (83 plots); white coating (89 plots); and whitish tumor (79 plots). Scatter diagrams and discriminating algorithms using spectrum signal intensity values were constructed and verified using validation datasets. StO2 values were compared between the tumors and tumor adherent substances using OS images of gastrointestinal tumors. Results The discriminating algorithms and their accuracy rates (AR) were as follows: blood vs. reddish tumor: Y> - 4.90X+7.13 (AR: 95.9%) and white coating vs. whitish tumor: Y< -0.52X +0.17 (AR: 96.0%). The StO2 values (median, [range]) were as follows: blood, 79.3% [37.8%–100.0%]; reddish tumor, 74.5% [62.0%–86.9%]; white coating, 73.8% [42.1%–100.0%]; and whitish tumor, 65.7% [53.0%–76.3%]. Conclusions OS imaging is strongly influenced by adherent substances for evaluating the specific StO2 value of tumors; therefore, it is important to eliminate the information of adherent substances for clinical application of OS imaging.

Original languageEnglish
Article numbere0243165
JournalPloS one
Volume16
Issue number1 January
DOIs
Publication statusPublished - Jan 2021
Externally publishedYes

ASJC Scopus subject areas

  • General

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