A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

Nobuyuki Kato; Makoto Hijikata; Yuko Ootsuyama; Masanori Nakagawa; Showgo Ohkoshi; Kunitada Shimotohno

doi:10.1111/j.1349-7006.1990.tb02518.x

A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

Nobuyuki Kato, Makoto Hijikata, Yuko Ootsuyama, Masanori Nakagawa, Showgo Ohkoshi, Kunitada Shimotohno

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

Original language	English
Pages (from-to)	1092-1094
Number of pages	3
Journal	Japanese Journal of Cancer Research
Volume	81
Issue number	11
DOIs	https://doi.org/10.1111/j.1349-7006.1990.tb02518.x
Publication status	Published - Nov 1990
Externally published	Yes

Keywords

Anti‐HCV
HCV expression
Hepatitis C virus (HCV)

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1990.tb02518.x

Cite this

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title = "A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection",

abstract = "A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.",

keywords = "Anti‐HCV, HCV expression, Hepatitis C virus (HCV)",

author = "Nobuyuki Kato and Makoto Hijikata and Yuko Ootsuyama and Masanori Nakagawa and Showgo Ohkoshi and Kunitada Shimotohno",

year = "1990",

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doi = "10.1111/j.1349-7006.1990.tb02518.x",

language = "English",

volume = "81",

pages = "1092--1094",

journal = "Cancer Science",

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T1 - A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

AU - Kato, Nobuyuki

AU - Hijikata, Makoto

AU - Ootsuyama, Yuko

AU - Nakagawa, Masanori

AU - Ohkoshi, Showgo

AU - Shimotohno, Kunitada

PY - 1990/11

Y1 - 1990/11

N2 - A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

AB - A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

KW - Anti‐HCV

KW - HCV expression

KW - Hepatitis C virus (HCV)

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SN - 1347-9032

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JO - Cancer Science

JF - Cancer Science

IS - 11

ER -

A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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