A structural protein encoded by the 5′ region of the hepatitis C virus genome efficiently detects viral infection

Nobuyuki Kato, Makoto Hijikata, Yuko Ootsuyama, Masanori Nakagawa, Showgo Ohkoshi, Kunitada Shimotohno

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non-structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

Original languageEnglish
Pages (from-to)1092-1094
Number of pages3
JournalJapanese Journal of Cancer Research
Volume81
Issue number11
Publication statusPublished - Nov 1990
Externally publishedYes

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Virus Diseases
Hepacivirus
Genome
Chronic Hepatitis
Serum
Hepatocellular Carcinoma
Proteins
Antibodies
In Vitro Techniques
hepatitis C virus C100 protein

Keywords

  • Anti-HCV
  • HCV expression
  • Hepatitis C virus (HCV)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kato, N., Hijikata, M., Ootsuyama, Y., Nakagawa, M., Ohkoshi, S., & Shimotohno, K. (1990). A structural protein encoded by the 5′ region of the hepatitis C virus genome efficiently detects viral infection. Japanese Journal of Cancer Research, 81(11), 1092-1094.

A structural protein encoded by the 5′ region of the hepatitis C virus genome efficiently detects viral infection. / Kato, Nobuyuki; Hijikata, Makoto; Ootsuyama, Yuko; Nakagawa, Masanori; Ohkoshi, Showgo; Shimotohno, Kunitada.

In: Japanese Journal of Cancer Research, Vol. 81, No. 11, 11.1990, p. 1092-1094.

Research output: Contribution to journalArticle

Kato, N, Hijikata, M, Ootsuyama, Y, Nakagawa, M, Ohkoshi, S & Shimotohno, K 1990, 'A structural protein encoded by the 5′ region of the hepatitis C virus genome efficiently detects viral infection', Japanese Journal of Cancer Research, vol. 81, no. 11, pp. 1092-1094.
Kato, Nobuyuki ; Hijikata, Makoto ; Ootsuyama, Yuko ; Nakagawa, Masanori ; Ohkoshi, Showgo ; Shimotohno, Kunitada. / A structural protein encoded by the 5′ region of the hepatitis C virus genome efficiently detects viral infection. In: Japanese Journal of Cancer Research. 1990 ; Vol. 81, No. 11. pp. 1092-1094.
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