A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

Nobuyuki Kato, Makoto Hijikata, Yuko Ootsuyama, Masanori Nakagawa, Showgo Ohkoshi, Kunitada Shimotohno

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

Original languageEnglish
Pages (from-to)1092-1094
Number of pages3
JournalJapanese Journal of Cancer Research
Volume81
Issue number11
DOIs
Publication statusPublished - Nov 1990
Externally publishedYes

Keywords

  • Anti‐HCV
  • HCV expression
  • Hepatitis C virus (HCV)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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