A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease

Shuhei Naka, R. Nomura, Yukiko Takashima, R. Okawa, T. Ooshima, K. Nakano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Streptococcus mutans, a major dental caries pathogen, has shown to be associated with the aggravation of cerebral hemorrhage and inflammatory bowel diseases. In this study, we evaluated the effects of S. mutans on the development of non-alcoholic steatohepatitis (NASH) in a mouse model. Materials and methods: Streptococcus mutans oral strain MT8148 (serotype c) and a blood isolate TW871 (k) were used. C57BL/6J mice (6 weeks old) were fed a high-fat diet for 4 weeks; the test strains or phosphate-buffered saline was then intravenously administered. Mice were euthanized after 8 or 12 weeks. Whole body, extirpated liver, and visceral fat weights were determined, and histopathological evaluations of the liver specimens were performed. Results: Mice infected with TW871 showed significantly greater body and liver weights than those administered MT8148 or phosphate-buffered saline. Histopathological analyses revealed prominent infiltration of inflammatory cells and adipocellular deposition in livers extirpated 8 weeks after an infection with TW871; fibrosis was also observed in livers extirpated after 12 weeks. Conclusion: These results suggest that a specific strain of S. mutans could induce NASH.

Original languageEnglish
Pages (from-to)700-706
Number of pages7
JournalOral Diseases
Volume20
Issue number7
DOIs
Publication statusPublished - Oct 1 2014
Externally publishedYes

Fingerprint

Streptococcus mutans
Liver
Fatty Liver
Phosphates
Intra-Abdominal Fat
Cerebral Hemorrhage
Dental Caries
High Fat Diet
Inbred C57BL Mouse
Inflammatory Bowel Diseases
Fibrosis
Body Weight
Non-alcoholic Fatty Liver Disease
Weights and Measures
Infection

Keywords

  • Streptococcus mutans
  • Mouse model
  • Non-alcoholic fatty liver diseases

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

Cite this

Naka, S., Nomura, R., Takashima, Y., Okawa, R., Ooshima, T., & Nakano, K. (2014). A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease. Oral Diseases, 20(7), 700-706. https://doi.org/10.1111/odi.12191

A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease. / Naka, Shuhei; Nomura, R.; Takashima, Yukiko; Okawa, R.; Ooshima, T.; Nakano, K.

In: Oral Diseases, Vol. 20, No. 7, 01.10.2014, p. 700-706.

Research output: Contribution to journalArticle

Naka, S, Nomura, R, Takashima, Y, Okawa, R, Ooshima, T & Nakano, K 2014, 'A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease', Oral Diseases, vol. 20, no. 7, pp. 700-706. https://doi.org/10.1111/odi.12191
Naka, Shuhei ; Nomura, R. ; Takashima, Yukiko ; Okawa, R. ; Ooshima, T. ; Nakano, K. / A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease. In: Oral Diseases. 2014 ; Vol. 20, No. 7. pp. 700-706.
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