A sofosbuvir-based direct-acting antiviral treatment regimen exhibits a strong protective effect against post-liver transplantation chronic hepatitis C recurrence

Atsushi Oyama, Akinobu Takaki, Tetsuya Yasunaka, Takuya Adachi, Fusao Ikeda, Nozomu Wada, Yasuhito Takeuchi, Hideki Ohnishi, Shinichiro Nakamura, Hidenori Shiraha, Kosei Takagi, Takashi Kuise, Daisuke Nobuoka, Ryuichi Yoshida, Yuzo Umeda, Mari Yoshida, Chisato Arimori, Takahito Yagi, Hiroyuki Okada

Research output: Contribution to journalArticle

Abstract

The efficacy and safety of anti-hepatitis C virus (HCV. direct-acting antivirals were evaluated in postorthotopic liver transplantation patients. There were 29 patients with HCV genotype 1 and 2 with genotype 2. Of the 29 genotype 1 patients, 5 received daclatasvir (DCV. + asunaprevir (ASV), and 25 received sofosbuvir (SOF. + ledipasvir (LDV), including 1 who had failed DCV + ASV. Both genotype 2 patients received SOF + ribavirin. Four patients with DCV + ASV completed the protocol, and 3 of them achieved a sustained viral re-sponse for 24 weeks (SVR24). All of the patients who received SOF + LDV and SOF + RBV achieved SVR24 with minor adverse events. In post-liver transplantation patients, SOF-based regimens showed highly satisfactory efficacy and safety.

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalActa Hepatologica Japonica
Volume58
Issue number11
DOIs
Publication statusPublished - Jan 1 2017

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Chronic Hepatitis C
Liver Transplantation
Antiviral Agents
Recurrence
Genotype
Therapeutics
Safety
Ribavirin
Sofosbuvir
Hepacivirus
asunaprevir

Keywords

  • Chronic hepatitis C
  • Direct acting antivirals (DAA)
  • Interferon free
  • Liver transplantation
  • Transplantation immunity

ASJC Scopus subject areas

  • Hepatology

Cite this

A sofosbuvir-based direct-acting antiviral treatment regimen exhibits a strong protective effect against post-liver transplantation chronic hepatitis C recurrence. / Oyama, Atsushi; Takaki, Akinobu; Yasunaka, Tetsuya; Adachi, Takuya; Ikeda, Fusao; Wada, Nozomu; Takeuchi, Yasuhito; Ohnishi, Hideki; Nakamura, Shinichiro; Shiraha, Hidenori; Takagi, Kosei; Kuise, Takashi; Nobuoka, Daisuke; Yoshida, Ryuichi; Umeda, Yuzo; Yoshida, Mari; Arimori, Chisato; Yagi, Takahito; Okada, Hiroyuki.

In: Acta Hepatologica Japonica, Vol. 58, No. 11, 01.01.2017, p. 599-604.

Research output: Contribution to journalArticle

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