A small-molecule approach to bone regenerative medicine in dentistry

Hiroshi Egusa, Makio Saeki, Masanori Doi, Sho Fukuyasu, Takuya Matsumoto, Yoshinori Kamisaki, Hirofumi Yatani

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The resorption of alveolar bone in periodontitis and/or following toothextraction results in a significant problem in an individual's oral health-related quality of life. Strategies employing growth factor proteins and/orstem cell-based therapy have been successfully used to regenerate alveolarbone augmentationregeneration/however, cost-effectiveness issues illustratethe need for developing alternative strategies. One promising approach is the development of conventional chemical and biological therapeuticsto strongly stimulate endogenous cells to regenerate. Small-molecule compounds can have a variety of biological functions, serving as cell signaling molecules, as tools in molecular biology, and as drugs in medicine. Therefore, the discovery of natural and novel small-molecule synthetic regulators of differentiation and maturation of osteoblasts and/or osteoclasts would acceleratethe development of bone regenerative medicine. Recently,"chemical biology" has started to play an increasingly important role in both drug discovery and elucidating the mechanism of biological phenomena. This review first addresses the current needs and strategies for alveolar bone regeneration, followed by the potential small molecules associated with bone regeneration, with a concluding section on chemical biology-based high throughput screening approaches for identifying small molecules targeting osteoblast/osteoclast differentiation.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalJournal of Oral Biosciences
Volume52
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

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Dentistry
Bone Regeneration
Regenerative Medicine
Osteoclasts
Osteoblasts
Bone
Alveolar Bone Loss
Biological Phenomena
Bone and Bones
Molecules
Periodontitis
Bone Development
Oral Health
Drug Discovery
Bone Resorption
Cell- and Tissue-Based Therapy
Cost-Benefit Analysis
Molecular Biology
Intercellular Signaling Peptides and Proteins
Quality of Life

Keywords

  • Bone regeneration
  • Chemical biology
  • Drug discovery
  • Regenerative dental medicine
  • Small-molecules

ASJC Scopus subject areas

  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)

Cite this

A small-molecule approach to bone regenerative medicine in dentistry. / Egusa, Hiroshi; Saeki, Makio; Doi, Masanori; Fukuyasu, Sho; Matsumoto, Takuya; Kamisaki, Yoshinori; Yatani, Hirofumi.

In: Journal of Oral Biosciences, Vol. 52, No. 2, 2010, p. 107-118.

Research output: Contribution to journalArticle

Egusa, H, Saeki, M, Doi, M, Fukuyasu, S, Matsumoto, T, Kamisaki, Y & Yatani, H 2010, 'A small-molecule approach to bone regenerative medicine in dentistry', Journal of Oral Biosciences, vol. 52, no. 2, pp. 107-118. https://doi.org/10.2330/joralbiosci.52.107
Egusa, Hiroshi ; Saeki, Makio ; Doi, Masanori ; Fukuyasu, Sho ; Matsumoto, Takuya ; Kamisaki, Yoshinori ; Yatani, Hirofumi. / A small-molecule approach to bone regenerative medicine in dentistry. In: Journal of Oral Biosciences. 2010 ; Vol. 52, No. 2. pp. 107-118.
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