A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins

Takehito Azuma; Hisao Moriya; Hayato Matsumuro; Hiroaki Kitano

doi:10.1109/CACSD-CCA-ISIC.2006.4776903

A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins

Takehito Azuma, Hisao Moriya, Hayato Matsumuro, Hiroaki Kitano

Research output: Contribution to conference › Paper › peer-review

6 Citations (Scopus)

Abstract

This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Wee1 proteins. The robustness of the eukaryoticcell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Wee1 proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

Original language	English
Pages	1734-1739
Number of pages	6
DOIs	https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776903
Publication status	Published - Dec 1 2006
Externally published	Yes
Event	2006 IEEE International Conference on Control Applications, CCA 2006 - Munich, Germany Duration: Oct 4 2006 → Oct 6 2006

Other

Other	2006 IEEE International Conference on Control Applications, CCA 2006
Country/Territory	Germany
City	Munich
Period	10/4/06 → 10/6/06

ASJC Scopus subject areas

Control and Systems Engineering
Computer Science Applications
Mathematics(all)

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10.1109/CACSD-CCA-ISIC.2006.4776903

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title = "A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins",

abstract = "This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Wee1 proteins. The robustness of the eukaryoticcell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Wee1 proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.",

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doi = "10.1109/CACSD-CCA-ISIC.2006.4776903",

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AU - Azuma, Takehito

AU - Moriya, Hisao

AU - Matsumuro, Hayato

AU - Kitano, Hiroaki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Wee1 proteins. The robustness of the eukaryoticcell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Wee1 proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

AB - This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Wee1 proteins. The robustness of the eukaryoticcell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Wee1 proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

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M3 - Paper

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T2 - 2006 IEEE International Conference on Control Applications, CCA 2006

Y2 - 4 October 2006 through 6 October 2006

ER -

A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins

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