A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins

Takehito Azuma, Hisao Moriya, Hayato Matsumuro, Hiroaki Kitano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Wee1 proteins. The robustness of the eukaryoticcell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Wee1 proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

Original languageEnglish
Title of host publicationProceedings of the IEEE International Conference on Control Applications
Pages1734-1739
Number of pages6
DOIs
Publication statusPublished - 2006
Externally publishedYes
Event2006 IEEE International Conference on Control Applications, CCA 2006 - Munich, Germany
Duration: Oct 4 2006Oct 6 2006

Other

Other2006 IEEE International Conference on Control Applications, CCA 2006
CountryGermany
CityMunich
Period10/4/0610/6/06

Fingerprint

Robustness Analysis
Cell Cycle
Cells
Proteins
Protein
Robustness
Sensitivity analysis
Sensitivity Analysis
Mathematical Model
Mathematical models
Model
Perturbation
Cycle
Numerical Examples
Demonstrate

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Mathematics(all)

Cite this

Azuma, T., Moriya, H., Matsumuro, H., & Kitano, H. (2006). A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins. In Proceedings of the IEEE International Conference on Control Applications (pp. 1734-1739). [4776903] https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776903

A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins. / Azuma, Takehito; Moriya, Hisao; Matsumuro, Hayato; Kitano, Hiroaki.

Proceedings of the IEEE International Conference on Control Applications. 2006. p. 1734-1739 4776903.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Azuma, T, Moriya, H, Matsumuro, H & Kitano, H 2006, A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins. in Proceedings of the IEEE International Conference on Control Applications., 4776903, pp. 1734-1739, 2006 IEEE International Conference on Control Applications, CCA 2006, Munich, Germany, 10/4/06. https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776903
Azuma T, Moriya H, Matsumuro H, Kitano H. A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins. In Proceedings of the IEEE International Conference on Control Applications. 2006. p. 1734-1739. 4776903 https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776903
Azuma, Takehito ; Moriya, Hisao ; Matsumuro, Hayato ; Kitano, Hiroaki. / A Robustness analysis of eukaryotic cell cycle concerning Cdc25 and Wee1 proteins. Proceedings of the IEEE International Conference on Control Applications. 2006. pp. 1734-1739
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